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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Are Cramps In Legs And Hands A Side Effect Of Consuming Bumetanide And/or Spironolactone?

I have COPD and PAH. I am taking Bumetanide 1mg per day and have started Spironolactone 25 mg per day. Since beginning Spironolactone 1/31/16 I have been getting leg and foot cramps. Usually at night when asleep. About 3 to 4 times per night. Now, I am getting leg and hand cramps during the day. Question: Could this be a side effect of either or both of these two drugs? Thank you.
Tue, 26 Apr 2016
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General & Family Physician,  's  Response
Hi.
The symptoms appear to be due to the side effects of Spironolactone.
Spironolactone is an Aldosterone receptor antagonist that causes the kidneys to remove sodium & water from the body with reduced losses of potassium which results into hyperkalemia (increased serum potassium level). The muscle cramps in the legs and hands occur due to hyperkalemia.
I would therefore advise you to stop taking Spironolactone immediately and consult your treating doctor for an alternate but a safer medication.
Hope this answers your query.
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Are Cramps In Legs And Hands A Side Effect Of Consuming Bumetanide And/or Spironolactone?

Hi. The symptoms appear to be due to the side effects of Spironolactone. Spironolactone is an Aldosterone receptor antagonist that causes the kidneys to remove sodium & water from the body with reduced losses of potassium which results into hyperkalemia (increased serum potassium level). The muscle cramps in the legs and hands occur due to hyperkalemia. I would therefore advise you to stop taking Spironolactone immediately and consult your treating doctor for an alternate but a safer medication. Hope this answers your query.