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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Sertraline Or Wellbutrin Cause Acid Reflux And Irritation In The Stomach?

I have been taking 200mgs of serrtaline for years. I also take 100 mgs. of Wellbutrin. My hands shake and I have thought that it is the drugs. I m exerencing very uncomfortable heartburn or irritation to the esophagus or stomach. I have had some of these symptoms to a lesser degree before. Because I have had anemia 3 times I have had an endoscopy, colonoscopy and swallowed a camera 2 years ago. The only thing that was found was a slight irritation to the top of the stomach. I have been on aciphex for the last 2 years which I understand cuts back on 90% of the acid. I m wondering if the sertraline or wellbutrin could be causing this problem. I have an appointment with my gastroenterologist in September but thought I would see what I can track down before then. Thanks
Fri, 14 Sep 2018
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General & Family Physician 's  Response
Hi,

I understand you have a concern about Sertraline or Wellbutrin causing heartburn. From my experience and what I've read, Sertraline and Wellbutrin do not usually cause this problem; there are some reports of Welbutrin causing gastric reflux, but this is very rare and I doubt it can explain the severity of your heartburn (as I assume you still have it even while taking Aciphex).

Aciphex is an appropriate treatment for your heartburn, and if you are still having symptoms while on it then I would recommend you see a gastroenterologist as well.

Hope I have answered your query. Let me know if I can assist you further.

Regards,
Dr. Aaron Branch, General & Family Physician
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Can Sertraline Or Wellbutrin Cause Acid Reflux And Irritation In The Stomach?

Hi, I understand you have a concern about Sertraline or Wellbutrin causing heartburn. From my experience and what I ve read, Sertraline and Wellbutrin do not usually cause this problem; there are some reports of Welbutrin causing gastric reflux, but this is very rare and I doubt it can explain the severity of your heartburn (as I assume you still have it even while taking Aciphex). Aciphex is an appropriate treatment for your heartburn, and if you are still having symptoms while on it then I would recommend you see a gastroenterologist as well. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Aaron Branch, General & Family Physician