Hello! I am a 51 year old male, otherwise healthy. However, in the past year, my PSA has elevated from a 1-2 to now being 11.2 as of the last test (12/30/2011.) The first elevated PSA came in back last February, and my PCP prescribed Cipro, 250mg, 2x daily, for 30 days, suspecting prostatitis, or, inflamation due to an infection. Subsequent PSA indicated a slightly reduced count, down from 7.5 to a 5.5. Later, after continuing regimen into May, the PSA dropped to 5.0. Over the summer, no antibiotics were taken. In August, PSA was back up to 8.0. Referred to a urologist for biopsy. Biopsy came back negative. PCP in October decided to take another route with prescribing Bactrim. November PSA came back as 9.9 Doctor freaked! I told him I d had relations the night before, and we decided to wait a couple of weeks to do it all over again. 12/30/2011 PCP prescribed 750mg Levaquin, 1x daily, for 90 days. At that time another PSA indicated a count of 11.2 (got those results today.) In addition, I ve presented with an elevated bilirubin count. It s at double the upper limit. Liver enzymes are also elevated. I presented with elevated bilirubin since fall of 2010. But since that time, the count dropped to within normal over the summer of 2011. We performed an upper-right quadrant sonogram, observing the liver, pancreas and gall bladder. Radiologist report came back negative for any signs of disease. My question: could the elevated bilirubin be causing a false positive, or affect the PSA test in any way? It s off track from that question, but if this is indeed an infection in my prostate, I have a strong sense that the pathology might be traced to a case of food poisoning, from August, 2010, upon eating food purchased at the food court at a local mall. Within an hour of ingestion, I suffered severe cramps, and later, vomiting and diarrhea. Stool became very pale; urine became very dark. Ironically, or coincidentally, this preceded by six months the PSA of 7.5 in February, 2010. My suspicions have long been that I ingested not listeria, but another bacterium, an enterococcus. As quoted from the handy Wikipedia (please excuse me): new epidemiological evidence has shown that enterococci are major infectious agent in chronic bacterial prostatitis. Enterococci are able to form biofilm in the prostate gland making their eradication difficult. Further, the article states that treatment should include either ampicillin or Vancomycin. And, in some cases where the strain may be resistant to Vancomycin, they indicate further: VRE may be treated with quinupristin/dalfopristin (Synercid) with response rates of approximately 70%.[7] Tigecycline has also been shown to have anti-enterococcal activity as has rifampicin.[1] It seems there might be some kind of connection between the elevated bilirubin and such an infection as well, as this bacterium can cause hemolysis, thus elevating the bilirubin. With the June sonogram indicating nothing outside the usual, a September biopsy coming back negative for cancer, yet an elevating PSA this past fall, coinciding with an elevated bilirubin count, yet a temporarily lower PSA AFTER completing the Cipro regimen, could it be that the Cipro was in fact inhibiting bacterial growth causing both issues to diminish over the summer?