I became suddenly intolerable (maybe) to all my six medications in the last two months A short history of my case is as follows. I am 69. In 2004 doctors told me that my high blood pressure is connected predominantly to the state of my kidneys (see below), and not to the state of the heart. I had brachytherapy a year and two months ago, and now PSA is good. Since2005 I have been taking the following medications: Hydralazine 25 mg tablet twice a day, Furosemide 40 mg tablet one a day, Lovostatin 40 mg tablet one a day, Losartin potassium 25 mg one a day, Metropol tartrate 25 mg one a day and Tamsulosin HCL 0.4 mg tablet one a day. I have been taking the medications during the period of 12 hours each day: from 1pm to about 1 am next day; with a cup of water with each medication and an interval of about two hours between medication takings. With all six previous medications I had not any problem from 2005 till the last two months ago. But in the last two months I have experienced hematuria. It had been being mild in the beginning of the aforementioned last two months, but it became very intense in the last three day. The hematuria at the beginning consisted of separated clots and a little blood, but in the last three days it has consisted of large amount of clots and blood. Hematuria was always preceding with rumbling and a little pain in the area below the right front ribs. The “schedule” of the hematuria: it starts by taking Hydralazine at 1pm and end at about 1 am next day, when I finished taking the medications for that day, i.e. it lasts for 12 hours each day, during taking of the medications. I am free of the hematuria from about 1am to 1pm next day, for about 12 hours each day, when I do not take the medications. I want to add the following fact that the hematuria is probably connected to the intolerance of the medications. In 2004 I became intolerable to Atenolol very suddenly, with a lot of hematuria, which was preceding with intense rumbling in the area of the stomach. When I had Atenolol switched to Hydralazine the hematuria completely stopped. The urologist sent me to CT and ultrasound to test the bladder, prostate and kidneys a month ago. The results didn’t show any worsening of these organ functions in respect to their previous state, i.e. before the last two months. The kidneys work well only 37 % of its capacity and have more cysts. The bladder had thickened wall. The cystoscopy is pending in 2 weeks. The urologist said maybe the hematuria is connected to side effect of the brachytherapy, but not to the intolerance to the medications. I await the answer to my above dilemma: is it possible to overcome the hematuria by switching to another set of similar medications; by dividing above doses into two or three smaller doses; by changing the manner how to take medications (for example, taking them with a food),or changing only some of above medications; or complete another approach . Thank you!