Is Amitriptyline or other related antidepressants worth the risk of harmful side effects with minor depression that may be due to the tramdo that I take for nerve damage? Also, If I am on tramadol, Gabapentin, and Carisoprodol, and Ibuprofen, is there any hazards in taking the Amitriptyline? @. Does Tramadol cause depression ? I am on a needed basis and try to substitute my meds for pain with the Ibuprofen because I have heard that the Gabapentin can cause memory loss and the tramadol can cause depression. I would prefer to stick to holictic as much as possible, and I know that some meds are a necessary factor in some cases.