I have been on Depo-Provera for 5 months now. Since taking the shot I have experienced increased severe anxiety, moderate depression, and all sorts of other unpleasant side effects. I am most concerned, however, with the mental side effects because I just want to get back to being me. I have heard about patients saying the mental side effects lasted until well after they went off of Depo, and I just wanted to know how true this is. I actually think I might be going crazy, but I'm hoping it's the Depo.