What Causes Fatigue,pedal Edema,breathlessness And Irregular Periods?

45 yrs female 78kg, last three years- variable BP 130/90 to 150/100

current complaints: easyily tired, pedal edema esp when legs not elevated, evenings, exertional breathlessness.



Also: menstrual cycles irregular since two years, currently spaced out- once in two months or so. leg /calf muscles pains, periodic stiffness and pain around finger joints esp one hand and sometimes knee.



ECG , echo and abdomen ultrasound- normal

Earlier treated for anemia

On Eltroxin (&5 mcg) for sev yrs and Telma H 40 mg for 6-7 months

Earlier tested positive for thyroid microsomal antibody : reactive (1:400) RA factor : 240

Currently Hb :13.8, ESR: 42, slightly increased leucocytes, Feritin: 49.2 ng/ml. Bilirubin: 21., direct Bilirubin: 1.1, A:G 1:2

ALT/SGPT: 40, SGOT:48, ALP :223. but GGT : 269. protein in urine; nil,creatinine: 1.0, earlier b12, 153, current: B12: 195, TSH; 2.94, random cortisol ( evening 6 pm)- below the reference range: 7.54 ug.dl

Do I have multiple problems or these symptoms connected? What s the meanings of the raised RA factor, abnormal findings on LFT, low random cortisol in the background of the symptoms mentioned,..?