i see 2 doctors, semi-regularly. one prescribes me hydrocodone/acetaminophen(10/325) for pain management. my other doctor is aware of this, and i asked if there was something a bit stronger due to tolerance buildup. he suggested a tagamet dose (cimetidine 400mg) prior to the hydrocodone dose for increased effects. when i brought this up to my first doctor, he told me that due to the metabolism of hydrocodone to hydromorphone, the tagamet would actually decrease the effects of hydrocodone, but it would increase other opiates such as oxycodone. which of my doctors is correct regarding tagamet's influence on hydrocodone specifically?