I was on the depo povera shot for heavy periods, after being on it for two years I started getting migraine, when I went to the hospital I found out I had a pituitary tumor, from prolactin. I was not on any other medications, I was healthy. Since being diagnosed I now have high blood pressure and cholesterol and possibly cushings. Could the depo be what caused the tumor? I have read it may be possible. I know of other ladies who have the same problem so we are all wondering. I hope you can help. Doctors around here have no clue. sorry I guess I can t get my answer I have not worked since may and have no money, thanks anyway