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I Just Read This After A Diagnosis Of MDS RCMD
I just read this after a diagnosis of MDS RCMD (about 6 months ago). This is from uptodate.com. I am not undergoing any treatment for mds, as I am defined as low intermediate based on other IPSS testing and then I find this:
Importantly, the following cytogenetic abnormalities, if found, result in the diagnosis of AML, regardless of blast count [126] (see "Clinical manifestations, pathologic features, and diagnosis of acute myeloid leukemia", section on 'Bone marrow infiltration'):
●t(8;21)(q22;q22); RUNX1-RUNX1T1 (previously AML1-ETO)
●inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11
●t(15;17)(q22;q21.1); PML-RARA
My cytogenic report states this:
SRSF2, RUNX1 and CEBPA mutations were detected by targeted next generation sequencing.
Should I be undergoing treatment now for AML?
Importantly, the following cytogenetic abnormalities, if found, result in the diagnosis of AML, regardless of blast count [126] (see "Clinical manifestations, pathologic features, and diagnosis of acute myeloid leukemia", section on 'Bone marrow infiltration'):
●t(8;21)(q22;q22); RUNX1-RUNX1T1 (previously AML1-ETO)
●inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11
●t(15;17)(q22;q21.1); PML-RARA
My cytogenic report states this:
SRSF2, RUNX1 and CEBPA mutations were detected by targeted next generation sequencing.
Should I be undergoing treatment now for AML?
Sun, 13 Mar 2016
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