I've always heard to take my thyroid med on an empty stomach first thing in the morning. My problem is I am up at 5am & drinking coffee by 5:15 in order to help wake up. I eat at 7ish and then am hungry for mid morn snack at 9:30, then eat lunch at 12:30. For the last few years, I've tried to take it about 4pm because that's about the only time I have a mostly empty stomach (between an lunch around 12:30 and dinner around 7:30). I'm not sure if that's a good plan or not, but If I take the med first thing, won't the coffee interfere? Not giving up the coffee at this point, so what do you advise?