My question is 2 years ago my ANA was 1:80, in July it was 1:160, this month it is 1:320 and the pattern changed. I also had an elevated reactive protein (twice what is should of been). all the RA tests have been negative. I'm still waiting on a diagnosis but was prescriped 20 mg of pred for 1 week and now taking 10 mg/day until I go back. Pink nose (no raised rash), Hair loss, fatigue, shortness of breath, blue fingers that are painful when its cold, and every joint in my body hurts. What is missing for a diagnosis? why the pred?