having taken tramadol for 16 weeks at a dose of 100mg, four times daily, I noticed certain things beginning to happen to me, I am suffering tremandous pain in my feet, just at the part of the foot where the toes start, and under the heels. This becomes worse with walking or just standing. My appetite has reduced, I feel quite aggressive and depressed too. My urine has changed colour and I am very apathetic.