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A 62 Yr Old Complained Of Irregular Periods For 6

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Posted on Sun, 14 Mar 2021
Question: A 62 Yr old complained of irregular periods for 6 months. XXXXXXX with BSO done one month back. Biopsy shows Gr2 mod diff papillary adenocarcinoma with less than 50 percent myometrial involvement.
Path staging PT1aNoM1.
Report of biopsy and post hysterectomy PET scan attached.

1) What next step of management?

2) some say chemotherapy and some Radiotherapy.

3) what's survival rate?
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Follow up: Dr. Indranil Ghosh (0 minute later)
A 62 Yr old complained of irregular periods for 6 months. XXXXXXX with BSO done one month back. Biopsy shows Gr2 mod diff papillary adenocarcinoma with less than 50 percent myometrial involvement.
Path staging PT1aNoM1.
Report of biopsy and post hysterectomy PET scan attached.

1) What next step of management?

2) some say chemotherapy and some Radiotherapy.

3) what's survival rate?
doctor
Answered by Dr. Indranil Ghosh (2 hours later)
Brief Answer:
Chemotherapy is standard

Detailed Answer:
Hi
Thanks for your query.

The reports show that that the disease has spread to pelvic peritoneum. At present, disease burden is probably not too high, as per the PET scan. But definitely it is stage IV.

So standard of care is chemotherapy. It is not curable with chemotherapy but can control it for some time. 5 yr survival is approximately 20-30%.

Hope this helps.
Regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
doctor
Answered by Dr. Indranil Ghosh (0 minute later)
Brief Answer:
Chemotherapy is standard

Detailed Answer:
Hi
Thanks for your query.

The reports show that that the disease has spread to pelvic peritoneum. At present, disease burden is probably not too high, as per the PET scan. But definitely it is stage IV.

So standard of care is chemotherapy. It is not curable with chemotherapy but can control it for some time. 5 yr survival is approximately 20-30%.

Hope this helps.
Regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Indranil Ghosh (4 days later)
Thank you for answers.
Doctor was suggesting a liposomal doxorubicin instead of conventional chemotherapy. Please explain adv & disadvantages.

How many cycles?

What's the kill rate of cancer cells?
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Follow up: Dr. Indranil Ghosh (0 minute later)
Thank you for answers.
Doctor was suggesting a liposomal doxorubicin instead of conventional chemotherapy. Please explain adv & disadvantages.

How many cycles?

What's the kill rate of cancer cells?
doctor
Answered by Dr. Indranil Ghosh (7 hours later)
Brief Answer:
Yes it can be given

Detailed Answer:
liposomal doxorubicin is not necessarily better than paclitaxel, but it has no or less hairfall, no body pain but more anemia and more nausea, mouth ulcers.

So basically the side effects are different. Six cycles usually given.

There's no such parameter as kill rate, tumor response is seen in 70% but unfortunately it comes back within average 1-2 years.

regards
Above answer was peer-reviewed by : Dr. Nagamani Ng
doctor
doctor
Answered by Dr. Indranil Ghosh (0 minute later)
Brief Answer:
Yes it can be given

Detailed Answer:
liposomal doxorubicin is not necessarily better than paclitaxel, but it has no or less hairfall, no body pain but more anemia and more nausea, mouth ulcers.

So basically the side effects are different. Six cycles usually given.

There's no such parameter as kill rate, tumor response is seen in 70% but unfortunately it comes back within average 1-2 years.

regards
Note: For further queries related to kidney problems Click here.

Above answer was peer-reviewed by : Dr. Nagamani Ng
doctor
Answered by
Dr.
Dr. Indranil Ghosh

Oncologist

Practicing since :2004

Answered : 1712 Questions

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A 62 Yr Old Complained Of Irregular Periods For 6

A 62 Yr old complained of irregular periods for 6 months. XXXXXXX with BSO done one month back. Biopsy shows Gr2 mod diff papillary adenocarcinoma with less than 50 percent myometrial involvement. Path staging PT1aNoM1. Report of biopsy and post hysterectomy PET scan attached. 1) What next step of management? 2) some say chemotherapy and some Radiotherapy. 3) what's survival rate?