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Are There Any Negative Interactions Between Wellbutrin, Vyvanse And Abilify?

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Posted on Mon, 20 Apr 2015
Question: I wanted to know if some medicines I'm taking have bad interactions?
The medications are: Wellbuterin, Vyvanse, Abilify, Klonopin
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Answered by Dr. Dr. Chintan Solanki (1 hour later)
Brief Answer:
interactions are there,only bad thing is chance of seizure if you are prone

Detailed Answer:
Hello,

Thanks for writing to us.

These four drugs may interact with each others.

Vyvanse increases toxicity of Wellbuterin by unspecified interaction mechanism.
Wellbuterin may cause seizures, especially at higher dosages, and combining it with other medications that can also cause seizures such as Vyvanse may increase that risk. The interaction may be more likely if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures. Significant interaction possible, monitor closely,keep Wellbuterin dose as low as possible.

Wellbuterin will increase the level or effect of Abilify by affecting hepatic enzyme CYP2D6 metabolism.Combining these medications may increase the risk of seizures, which may occur rarely with either medication. Wllbutrin can increase the blood levels of Abilify, which may increase other side effects.

Klonopin and Abilify both increase sedation.They may increase side effects such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience some impairment in thinking and judgment. Use with caution while you are driving or working with machines.

Though no other specific interactions have been noted, one should always be careful. By chance if you fine some side effects, consult your doctor immediately.

Hope I have answered your query, I will be happy to help further.

Regards,
Dr.Chintan Solanki.
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Yogesh D
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Answered by
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Dr. Dr. Chintan Solanki

Psychiatrist

Practicing since :2007

Answered : 2407 Questions

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Are There Any Negative Interactions Between Wellbutrin, Vyvanse And Abilify?

Brief Answer: interactions are there,only bad thing is chance of seizure if you are prone Detailed Answer: Hello, Thanks for writing to us. These four drugs may interact with each others. Vyvanse increases toxicity of Wellbuterin by unspecified interaction mechanism. Wellbuterin may cause seizures, especially at higher dosages, and combining it with other medications that can also cause seizures such as Vyvanse may increase that risk. The interaction may be more likely if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures. Significant interaction possible, monitor closely,keep Wellbuterin dose as low as possible. Wellbuterin will increase the level or effect of Abilify by affecting hepatic enzyme CYP2D6 metabolism.Combining these medications may increase the risk of seizures, which may occur rarely with either medication. Wllbutrin can increase the blood levels of Abilify, which may increase other side effects. Klonopin and Abilify both increase sedation.They may increase side effects such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience some impairment in thinking and judgment. Use with caution while you are driving or working with machines. Though no other specific interactions have been noted, one should always be careful. By chance if you fine some side effects, consult your doctor immediately. Hope I have answered your query, I will be happy to help further. Regards, Dr.Chintan Solanki.