Brief Answer: no , not a known side effect Detailed Answer: HI, thanks for using healthcare magic Alprazolam is a benzodiazepine, it is not in the narcotic family of medications. It can be associated with different potential side effects that may or may not occur. In terms of depression- when compared to placebo (persons not getting any medication)- 13.9% of the persons using alprazolam developed depression but it occurred in 18.1 of the persons who did not get the alprazolam In another study , depression occurred in approximately 13.8% of those who got the alprazolam and 14% of those who got nothing. This means that depression is a side effect that is as common or in some cases less common in persons with alprazolam. Commonly it is used in the initial stage of depression treatment because it helps with sleeping but it persons who use it do not develop depression because of it. It is associated with drowsiness, fatigue, problems with coordination and memory among other side effects. Oxycodone- is a narcotic. It can cause different effects including drowsiness and dizziness but it is not known to cause depression. SUMMARY Both of these medications can cause potential side effects but : (1)oxycodone is not associated with causing depression and (2)alprazolam can be associated with depression but the chance is less or the same as the general population The mixture would not cause an increased chance of depression. I hope this helps, feel free to ask any other questions

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