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Can Chromosomal Abnormalities Cause Miscarriage Issues?

Posted on Mon, 5 Aug 2024

Question: Hello. We have miscarriage issues. 4 miscarriages since our marriage (6 years). Fetal pole seen and egg yolk also developed but no heart beat. This causes missed abortion. Wife reports are normal. No issue on conceiving. In Semen analysis, sperm count is 169 million/ml, pH 7.5. Rest are as follows:

Percent motile sperm 79.8%
Rapid Linear Progression 17.71%
Slow/Non linear progression 40.8%
Non Progressive 21.3%
Immotile 20%
Normal form 40%
Abnormal 60%

Answered by Dr. Mahesh Koregol (2 hours later)

Brief Answer:
Chromosomal abnormalities needs to be checked

Detailed Answer:
Hi,
I saw your attached reports and concerns about miscarriages.
Following is my reply:
1) Semen parameters, Ultrasound reports seem to be normal.
2) Repeated Miscarriages are possible due to chromosomal abnormalities in the fetus.
3) Please do Karyotyping blood test of husband and wife to check if there are chromosomal problems in you both.
4) You might need to undergo IVF with preimplantation genetic screening of embryos to identify normal embryos.

Update me your Karyotyping blood test so that I can guide further.

Regards

Above answer was peer-reviewed by : Dr. Nagamani Ng

Follow up: Dr. Mahesh Koregol (4 days later)

Dear

We are already done with Karyo typing earlier. Please find attached reports for your reference.

Answered by Dr. Mahesh Koregol (53 minutes later)

Brief Answer:
Preimplantation Genetic Screening Required

Detailed Answer:
Hi,
Thanks for sharing reports.
Since you are 34 years old and there is history of multiple miscarriages, it is probably due to chromosomal abnormalities in the fetus.
Though Karyotyping reports of you both are normal, there is possibility of fetus being chromosomally abnormal leading to miscarriages.
I advise you to undergo IVF /ICSI with preimplantation y Screening of embryos to rule out abnormal embryo before embryo transfer.
Also get Hysteroscopy of uterus to check small unseen polyps or septum in uterus.
Let me know if you need any help.
Regards

Above answer was peer-reviewed by : Dr. LAKSHMI

Follow up: Dr. Mahesh Koregol (3 days later)

Can you please check Prolactin recent report. It is high. Can it be a reason for miscarriage? What to do to reduce it?

Answered by Dr. Mahesh Koregol (21 hours later)

Brief Answer:
High prolactin

Detailed Answer:
Hi,
High prolactin levels can be treated with cabergolin tablets with prescription from your doctor.
Your prolactin levels are slightly high and can be easily treated.

Above answer was peer-reviewed by : Dr. Nagamani Ng