Can Diphenhydramine Be Taken Along With Phenergan?

Posted on Sat, 12 Dec 2015

Question: hello i was wondering can u use diphenhydramine with phenergan at same time 2 help sleep

Answered by Dr. Muhammad Hanif (21 minutes later)

Brief Answer:
Don't use both of them concomitantly. Phenergan is good for that!

Detailed Answer:
Thanks for the consultation at my virtual clinic!
I have carefully worked through your case, and can well realize your health worries. Being your physician, I will take care all of your medical concerns today and will put my best efforts to get you out of this situation.

No you better not mix both of them at the same time as both have almost the same effects on body and if taken together, may lead to antihistamine overdosage. It may cause CNS depression and other bodily side effects. Instead of getting out of bed afresh the person may be even more lethargic and miserable if he takes both the medicines together before going to sleep.

We usually give Phenergan for sound and peaceful sleep and to relieve the anxiety. You can take that but don't mix it then with Diphenhydramine.

Hope I answered all of your questions. Let me know if you have further clinical concerns or doubts. I will be more than happy to get back to you with expert opinion. Please don't forget to give Five Star rating to help me assist my patients in a better way; and, please don't forget to 'Close This Discussion'.
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Regards!
DR. XXXXXXX HANIF
USA

Above answer was peer-reviewed by : Dr. Sonia Raina

Follow up: Dr. Muhammad Hanif (14 days later)

hcme2927 hello was wondering wood it b safe 2 take doxylamine succinate 25 mg with phenagrin 25 mg 2 help me sleep

Answered by Dr. Muhammad Hanif (27 minutes later)

Brief Answer:
Usually not recommended to take the both of them at the same time!

Detailed Answer:
Thanks for choosing HCM as your health partner. I appreciate your follow up on the issue and happy to assist you today with the query you raised.

Promethazine (Phenergan) and Doxylamine are both the drugs that cause sedation and if taken together may cause increased sedative effects and can be dangerous. I usually don't recommend my patients to take them together due to serious pharmacologic drug interaction between the two.

If you have to take it, close monitoring by a prescribing Physician is highly recommended.

Hope I answered all of your questions. Let me know if you have further clinical concerns or doubts related to any of the health issues you have. I will be more than happy to get back to you with expert opinion. Please don't forget to give Five Star rating to help me assist my patients in a better way; and, please don't forget to 'Close This Discussion'.
For any disease you have, a timely follow-up is very necessary regarding the treatment efficacy and to see if there is a need to change the treatment options. So keep a follow up to see how you doing (Always write down my name in the start of your questions at this forum & I will be with you in no time).

Regards!
DR. XXXXXXX HANIF
USA

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Above answer was peer-reviewed by : Dr. Raju A.T