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Can Metformin Be Taken Throughout The First Trimester?

Posted on Sat, 11 Apr 2015

Question: Hi doctor, i am 32 and 5 and a half weeks pregnant. I had pcos but not a chronic condition. I was put on metformin since last year july 2014 and continued taking it since then. Now upon finding out i m pregnant doctor asked me to continue 500mg of metformin everyday until 13th week. Also, she has asked me to take duphaston twice a day until 13th week. I wanted to know if this medication is fine to take all the way till first trimester. Thanks

Answered by Dr. Mahesh Koregol (1 hour later)

Brief Answer:
It is safe to take this medicine

Detailed Answer:
Hi,

Thanks for your query.

I read your query and I understand your concerns about metformin and duphaston safety.

Following is my reply:

1) Metformin and duphaston are safe drugs.

2) You can continue them in first trimester.

3) There will be no effects on the fetus.

I hope I answered your query. I will be available for any follow up query you have.

Regards,
Dr. Mahesh Koregol

Above answer was peer-reviewed by : Dr. Pradeep Vitta

Follow up: Dr. Mahesh Koregol (28 hours later)

Thanks Dr. XXXXXXX for the response. However, i checked my sugar level and its 86 so do i still continue metformin?

Answered by Dr. Mahesh Koregol (8 hours later)

Brief Answer:
You can stop metformin

Detailed Answer:
Hi

You can stop metformin now. Its not needed any longer.

Whatever you have taken till now wont cause any problem to baby. Dont worry about it.

If wish to ask any question to me directly next time please click on following link:

http://bit.ly/askdrmaheshkoregol

Regards

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Mahesh Koregol (34 hours later)

Hi Dr. XXXXXXX Can i just abruptly stop? Will it not bring in fluctuations in the insulin level? I hear metformin also reduces the changes of miscarriage?
Also, duphaston i m taking is orally and its 10mg, twice a day. Is this dosage fine? Is progestrone by insertion better than taking orally? Thanks again

Answered by Dr. Mahesh Koregol (8 minutes later)

Brief Answer:
You can stop abruptly

Detailed Answer:
Hi,

Yes. You can abruptly stop. No problem. It wont alter insulin levels now. Metformin is not related to miscarriage.

Continue Duphaston 10 mg orally twice daily. This is good enough orally and absorption is also good.

Let me know if you need any more clarifications.

Regards

Above answer was peer-reviewed by : Dr. Pradeep Vitta

Follow up: Dr. Mahesh Koregol (3 days later)

Hi Dr. XXXXXXX Thanks for your earlier feedbacks.
I checked my serum progesterone level and its 11ng/ml. I start 7 weeks today. Do you think its low and progesterone dosage should be increased? I am on 10mg duphaston twice a day now.

Answered by Dr. Mahesh Koregol (3 minutes later)

Brief Answer:
Yes

Detailed Answer:
Hi,

You can take Inj. Susten 100mg once in 3 days. This will give good progesterone support.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Mahesh Koregol (7 hours later)

Hi dr. I started 200mg susten 200 twice a day upon consultation. Thank you.

Answered by Dr. Mahesh Koregol (6 hours later)

Brief Answer:
Good

Detailed Answer:
Hi

Good. This will help you. Continue susten.
In future you can contact me directly to ask questions by clicking following link:

http://bit.ly/askdrmaheshkoregol

Above answer was peer-reviewed by : Dr. Raju A.T