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Can Mirtazapine And Nortriptyline Be Taken Together?

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Posted on Wed, 17 Sep 2014
Question: Can you take 15 mg. of mirtazapine and 25 mg. of nortriptyline at the same time. I
am having stomach aches all day and they let up in the evening but then start all over
in the morning.
doctor
Answered by Dr. Dr. Rovena (1 hour later)
Brief Answer:
You should avoid this drug combination.

Detailed Answer:
Hello!
Thank you for posting your query in HealthcareMagic.
I had gone through your query.

There is a major interaction between these two drugs and this combination should be avoided.
Combining these medications can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death.

I suggest to discuss this with your treating doctor before taking these drugs together.

Hope it was of help.
Let me know if you have other questions or doubt to clarify.

Take care!
Dr.Rovena Murati
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Dr. Rovena

General & Family Physician

Practicing since :2013

Answered : 1243 Questions

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Can Mirtazapine And Nortriptyline Be Taken Together?

Brief Answer: You should avoid this drug combination. Detailed Answer: Hello! Thank you for posting your query in HealthcareMagic. I had gone through your query. There is a major interaction between these two drugs and this combination should be avoided. Combining these medications can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. I suggest to discuss this with your treating doctor before taking these drugs together. Hope it was of help. Let me know if you have other questions or doubt to clarify. Take care! Dr.Rovena Murati