Brief Answer:
Potential interactions between tizanidine and valsartan can occur.

Detailed Answer:
Hello!

Thank you for asking on HCM!

Regarding your concern, I would explain that tizanidine can increase the effects of valsartan by pharmacodynamic synergism (they both reduce blood pressure), leading to potential low blood pressure (hypotension).


I recommend to use it with caution, in small doses and be alert to possible alarm signs of hypotension like lightheadedness, dizziness, fatigue and possible fainting or falling.

You should discuss with your attending physician on this issue, and try to find a solution for this interaction between the two drugs (use lower doses by tappering slowly or switch to another drug other that tizanidine).

Hope to have been helpful!

Feel free to ask any other questions whenever you need.

Best wishes,

Dr. Iliri

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