Can You Please Tell Me What Polyclonal Increase ?

Posted on Mon, 24 Mar 2025

Question: Hi Dr, can you pleaae tell me what polyclonal increase indicates? Labs uploaded. Thank you

Answered by Dr. Indranil Ghosh (4 hours later)

Brief Answer:
It signifies benign cause

Detailed Answer:
Hi
Thanks for your query.

These reports suggest increase in immunoglobulin due to non malignant cause. Maybe old or recent infection, rheumatic disorders, liver disease, etc. Sometimes no cause is found.

This is not due to multiple myeloma or lymphoma.

Hope this helps
Regards

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Indranil Ghosh (5 hours later)

Thank you Dr.

One last question, say said patient just has weight loss and no other symptoms. How would you investigate for non hematologic malignancy in this patient?

Would patient need to see several doctors to do investigation of malignancy?

Answered by Dr. Indranil Ghosh (6 hours later)

Brief Answer:
Depends on the degree of weight loss

Detailed Answer:
If there's significant weight loss, like 10% in 6months, then we should investigate.

Usually we do PET CT whole body, upper GI endoscopy and colonoscopy for screening.

An internal medicine specialist can do all the investigations.

Regards

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Indranil Ghosh (2 hours later)

Thank you Dr

Answered by Dr. Indranil Ghosh (12 hours later)

Brief Answer:
you are welcome

Detailed Answer:
Regards

Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar