Brief Answer:
High kappa chains and high ratio can be due to MGUS

Detailed Answer:
Hello,
The lab results show elevated kappa chains and high kappa to lambda chain ratio.
High kappa chains and high kappa to lambda ratio in the absence of M-spike can be due to MGUS.
In addition, I suggest you to get immunofixation in serum and urine.
Heavy chain assay should also be done to rule out any other gammopathy.
Symptoms of leg pain and fatigue could be due to some connective tissue disorder.
I also suggest you to consult a rheumatologist for clinical assessment to look for probable cause of fatigue and leg pain.
If you have more queries, I will be glad to answer.

Thanks and take care
Dr Shailja Puri

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Brief Answer:
Presence of monoclonal protein suggest MGUS

Detailed Answer:
Hello and welcome again,
Presence of isolated kappa light chains is suggestive of MGUS.
You need to remain in touch with your rheumatologist and hematologist.
MGUS has an indolent course and may or may not progress to myeloma or similar disease.
Regular follow up is required and there is nothing much to worry.

Thanks and take care
Dr Shailja Puri

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Brief Answer:
There is no evidence of multiple myeloma currently

Detailed Answer:
Hello and welcome again,
There is absence of M-spike thus multiple myeloma is unlikely.
MGUS does not necessarily progress to multiple myeloma.
However, regular follow up is required.

Thanks and take cate
Dr Shailja Puri

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