Brief Answer:
I don't think you need to be concerned...

Detailed Answer:
Dear sir,

I went through the details provided with diligence. And in my opinion you have a few symptoms which are part of normal physiology perhaps a bit exaggerated due to previous medical ailments. Let me explain.

1. While running, there is increased work load on leg muscles. Nature has a designed our body to gush blood to areas in times of excess load. Therefore gushing of blood to lower limbs is normal. One doesn't notice this change if he is not observing keenly. The gushing of blood and warming is due to increased blood supply to the working muscles - that's normal physiology.
2. Long standing diabetes increase chances of autonomic neuropathy. Normal physiological response of blood vessels is slightly lowered in presence of autonomic neuropathy. Thus what is normal may be slightly exaggerated in you.
3. Stress and exertion stimulates gastric secretions leading to hyperacidity and heart burns, especially in men who are susceptible to it.
4. Lastly anxious nature of individual can alter the way normal responses are. Controlling anxiety takes care of those.

In brief, since all the major tests of heart is normal, you need be concerned about serious problems. The symptoms you have may be due to - your keen observation + long standing diabetes induced neuropathy + probably anxious behaviour. Since the symptoms are of split second duration, we need not explore further and treat it. You can definitely do specific changes such as:
- Avoid jogging. Instead try brisk walking.
- Lower the amount of strenuous exercise.
- Continue to keep your sugars under control. Uncontrolled sugars can worsen existing neuropathy
- Take proton pump inhibitor for hyperacidity. I suggest tablet pantoprazole 40mg before breakfast for couple of weeks in my patients with hyperacidity.
- Manage stress and anxiety (if any). Take professional help if they are interfering with your daily activities.
- Lastly it is better to also test your vitamin B12 levels. If they are deficient, it needs to be corrected as well.

Hope this approach of treatment helps you. Write back for enquiries.

Regards

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Brief Answer:
Remote possibility of medicine side effects...

Detailed Answer:
Hi,

Most of my patient tolerate 500mg of metformin very well. Besides, the split second symptoms are unlikely to be due to medical side effects. I would expect the side effects to remain until you receive symptomatic drugs and remove the culprit drugs.

You can definitely discuss about this concern with your treating doctor / board certified physician, if you feel they are related. He can consider changing medicines and see if you feel better with others. But I really don't think medicines have any role.

Thanks for sharing this concern. You can write back for clarification.
Please close this discussion if you have no more queries.

Regards

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