Brief Answer:
About clomid and GABA receptors:

Detailed Answer:

Hello,

There are hypothesis that different hormone imbalances can affect the neurotransmitters of central nervous system but nothing is approved until now.

So, what we do in our daily practice is suggesting the patients stop the treatment if there are signs or symptoms of central nervous system implication.

Otherwise, you may continue Clomid without a problem.

Hope I have answered your query. Let me know if I can assist you further.

Regards,
Dr. Mirjeta Guni, Endocrinologist

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Brief Answer:
About neurosteroids...

Detailed Answer:

Hi,

Now the questions seem to be more clear.

Neurosteroids are steroids synthesized within the brain and modulate neuronal excitability resulting in improvement of anxiety.

They modulate brain excitability primarily by interaction with neuronal membrane receptors and ion channels, principally GABA-A receptors.

Testosterone-derived androgens such as androstanediol (5α-androstane-3α,17β-diol) and estradiol can be considered as neurosteroids, clomiphene reduces the estrogen levels do cannot be considered as a neurosteroid.

I do not think clomiphene will have an effect in improving anxiety as other neurosteroids do.

Hope I have answered your query.

Regards,
Dr. Mirjeta Guni, Endocrinologist

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