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Does Glimepiride Interact With Metformin?

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Posted on Fri, 24 Mar 2017
Question: Can you combine insulin metformin and glimepiride ?
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Answered by Dr. Mirjeta Guni (24 minutes later)
Brief Answer:
This combination is not recommended;

Detailed Answer:
Hello and thank you for asking!

Once you start insulin, Glimepiride is recommended to be discontinued, first: because you are taking insulin from outside, there is no need to stimulate pancreas with Glimepiride.

Secondly: the risk for hypoglycemia is greater with insulin and Glimepiride.

Metformin and insulin, yes, especially if the patient is overweight.

Hope the information will help.

Kind regards,
Dr.Mirjeta

Note: For further follow-up, discuss your blood glucose reports with our diabetologist. Click here.

Above answer was peer-reviewed by : Dr. Arnab Banerjee
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Answered by
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Dr. Mirjeta Guni

Endocrinologist

Practicing since :2006

Answered : 2413 Questions

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Does Glimepiride Interact With Metformin?

Brief Answer: This combination is not recommended; Detailed Answer: Hello and thank you for asking! Once you start insulin, Glimepiride is recommended to be discontinued, first: because you are taking insulin from outside, there is no need to stimulate pancreas with Glimepiride. Secondly: the risk for hypoglycemia is greater with insulin and Glimepiride. Metformin and insulin, yes, especially if the patient is overweight. Hope the information will help. Kind regards, Dr.Mirjeta