Does Methylnaltrexone Help Prevent Ileus?

Posted on Wed, 5 Jul 2017

Question:
fiber, stool softners q day laxitive every dayy dr say ileus quit started again 3 days later happening for 2 years getting big gut and upset stmach alit. what can be done

Answered by Dr. Ramesh Kumar (1 hour later)

Brief Answer:
Details below.

Detailed Answer:

Hi,
Thanks for choosing HealthcareMagic for your query.
As per your query answers are-
As normal conventional treatment is not helping much discuss the options mentioned below with your Gastroenterologist.
Stimulation of gastrointestinal opioid receptors can theoretically influence gastrointestinal motility directly. Alvimopan and methylnaltrexone are two drugs. Both appear to offer promising results for preventing recurrent ileus.

Neostigmine is an acetylcholinsterase inhibitor that causes an increase in cholinergic activity in the gut wall, which is believed to thereby stimulate colonic motility.

Edrophonium chloride and bethanechol chloride,can be used which inhibit acetylcholine has been reported to show improvement.
Metocloprimide is suspected to enhance gastrointestinal motility without stimulating gastric secretion.
Cisapride is a serotonin receptor antagonist that promotes acetylcholine release from nerve endings and is thought to improve gastrointestinal motility.

All of them can be used to managhe symptoms.
Discuss this with your treating Gastroenterologist.

Thank you

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Above answer was peer-reviewed by : Dr. Remy Koshy