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Does Pravastatin Interact With Methotrexate?

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Posted on Tue, 14 Mar 2017
Question: Is there any negative drug reaction when taking Pravastatin and Methotrexate?
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Answered by Dr. Panagiotis Zografakis (1 hour later)
Brief Answer:
they both may cause liver problems

Detailed Answer:
Hello,

methotrexate frequently causes liver problems with elevated liver function tests. Pravastatin also has some potential for liver damage. Using together two drugs that may cause liver problems increases the risk for side effects although there is no direct interaction between them. Using more hepatotoxic drugs is also discouraged.

Kind Regards!
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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Panagiotis Zografakis

Internal Medicine Specialist

Practicing since :1999

Answered : 3815 Questions

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Does Pravastatin Interact With Methotrexate?

Brief Answer: they both may cause liver problems Detailed Answer: Hello, methotrexate frequently causes liver problems with elevated liver function tests. Pravastatin also has some potential for liver damage. Using together two drugs that may cause liver problems increases the risk for side effects although there is no direct interaction between them. Using more hepatotoxic drugs is also discouraged. Kind Regards!