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Does Provigil Cause Agitation?

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Posted on Thu, 8 Oct 2015
Question: I Wonder if provigil is causing agitation after time. The first time I took provigil (adrafinil 300 mg actually) I got sweaty, confused, and somewhat afraid. It all went away when I took my morning klonopin and lamictal. from that point it has helped me with concentration and mood.
I've been taking it on and off for a couple of weeks as I'm worried about my liver. The last two times I took it I felt myself getting irritable and somewhat nervous.

I thought provigil was supposed to not have these effects, but drugs with adrenergic effects tend to hit me poorly (buspar, wellbutrin, serzone, desipramine). I may be looking at this the wrong way. I currently take celexa and Lamictal, and I have had to increase my celexa by 10 mgs recently to help with my depression. not sure if maybe I am getting an agitation from all three somehow.

Can these effects build over time with this drug? I'm wondering if I should just put it down altogether, or maybe lower my dose (although I think 300mg adrafinil=100mg provigil).

thanks
doctor
Answered by Dr. Alexander H. Sheppe (3 hours later)
Brief Answer:
Provigil side effects

Detailed Answer:
Thanks for the excellent question.

A lot of your theorizing is actually probably true. Provigil can cause the symptoms you are describing, and the first thing I would do is try a lower dose. Sometimes, however, people initially respond to antidepressant (Celexa) increases with paradoxical agitation/anxiety. I would give it a couple weeks on the Celexa and see if the anxiety wears off as your body gets used to the higher dose.

For a more complete evaluation, ask me below:
tinyurl.com/DrSheppeAnswers
Note: For further guidance on mental health, Click here.

Above answer was peer-reviewed by : Dr. Neel Kudchadkar
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Answered by
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Dr. Alexander H. Sheppe

Psychiatrist

Practicing since :2014

Answered : 2236 Questions

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Does Provigil Cause Agitation?

Brief Answer: Provigil side effects Detailed Answer: Thanks for the excellent question. A lot of your theorizing is actually probably true. Provigil can cause the symptoms you are describing, and the first thing I would do is try a lower dose. Sometimes, however, people initially respond to antidepressant (Celexa) increases with paradoxical agitation/anxiety. I would give it a couple weeks on the Celexa and see if the anxiety wears off as your body gets used to the higher dose. For a more complete evaluation, ask me below: tinyurl.com/DrSheppeAnswers