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Does Testosterone Enanthate Affect The Gabba Receptors In The Brain?

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Posted on Fri, 14 Apr 2023
Question: Hi I wanted to ask does Testosterone Enanthate effect any of the gabba ln your brain and does cloud effect gabba receptors as I am currently doing a 5month benzo tapering and have kindled twice in this time. Would using clomideffect gabba too?
doctor
Answered by Dr. Mirjeta Guni (3 hours later)
Brief Answer:

Testosterone and GABA receptors:

Detailed Answer:

Hello,

The effect of testosterone in GABA receptors is studied only in rats, administration of testosterone enanthate induces anxiolytic-like behaviors in the rats.

I have to say also that this effect of testosterone is seen only in studies done with intracranial injections and not intramuscular injections. So this is still a puzzle.

Regarding Clomid, they may also have an effect on GABA receptor (due to estrogen increase) but no study in humans is concluded.

So, while taking testosterone you may use also benzodiazepines as it injections seems to have no effect on GABA receptors.

Hope I have answered your query. Let me know if I can assist you further.

Take care

Regards,
Dr Mirjeta Guni, Endocrinologist
Above answer was peer-reviewed by : Dr. Raju A.T
doctor
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Follow up: Dr. Mirjeta Guni (2 hours later)
I have already kindled my taper a couple of times and feel like I will not survive. I have upped my dose as I had no choice to and taper slow. These burning sensations that I feel in My body and feel that I can't shut off is it part of excotoxity?
doctor
Answered by Dr. Mirjeta Guni (13 hours later)
Brief Answer:

About burning sensation;

Detailed Answer:

Hi,

You should check testosterone level before each injection in order to be sure that the dose you are taking is correct.

Anyway, burning sensation is not related to testosterone over or under dosage, you should check electrolytes such as calcium, magnesium, vit B12 and correct each of them if necessary.

Hope I have answered your query.

Take care

Regards,
Dr Mirjeta Guni, Endocrinologist
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Above answer was peer-reviewed by : Dr. Prasad
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Answered by
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Dr. Mirjeta Guni

Endocrinologist

Practicing since :2006

Answered : 2414 Questions

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Does Testosterone Enanthate Affect The Gabba Receptors In The Brain?

Brief Answer: Testosterone and GABA receptors: Detailed Answer: Hello, The effect of testosterone in GABA receptors is studied only in rats, administration of testosterone enanthate induces anxiolytic-like behaviors in the rats. I have to say also that this effect of testosterone is seen only in studies done with intracranial injections and not intramuscular injections. So this is still a puzzle. Regarding Clomid, they may also have an effect on GABA receptor (due to estrogen increase) but no study in humans is concluded. So, while taking testosterone you may use also benzodiazepines as it injections seems to have no effect on GABA receptors. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Mirjeta Guni, Endocrinologist