Brief Answer: Please consult your doctor before any plan Detailed Answer: Hi, Thanks for the query. Arava has got long elimination time from the body. A regular use of Arava requires a drug elimination procedure to be employed before the planning for pregnancy. Without this, the active metabolite of drug may take upto 2 years for elimination from body. Monitoring of plasma levels of the active metabolite (M1) s required before planning pregnancy and a level of less than 0.02 mg/L (0.02 μg/mL) is expected to have minimal risk based on available animal data. All these statements hold for females and available information does not suggest that ARAVA would be associated with an increased risk of male-mediated fetal toxicity. However, animal studies to evaluate this specific risk have not been conducted. To minimize any possible risk, men wishing to father a child should consider discontinuing use of ARAVA and taking cholestyramine 8 grams 3 times daily for 11 days. All these things can only be done in consultation with a specialist and please do not venture to go for this on your own. Whether you plan to go for pregnancy after a single tablet or a six month trial or for freezing the sperms, please go for estimation of plasma levels of active metabolite (M1) of the drug. Feel free to ask another query. Regards

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Brief Answer: No evidence in literature to comment on ur stutus Detailed Answer: Thanks for the query. As such there is no evidence in literature regarding the effect of drug on male associated fetal abnormalities. So commenting on your condition with evidence is not possible. Without evidence I would like to suggest that you should go for plasma level estimation of active metabolite and if the levels are below the permissible limit as stated in previous reply, please go ahead with your plans. Feel free to ask another query. Regards

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