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Does Drinking Excessive Amounts Of Water Reduce The Effectiveness Of Anti-TB Medication?

Posted on Thu, 2 Mar 2017

Question: sir with anti tubercular lymphadentis treatment for last three months I have query
1) is taking four tablets of Akurit 3 with two or more glass of water will make them less effective for that particular day dosage.i regularly used to drink more water in morning so took tablets by mistake for one week with more water .will this make tablets in effective for that particular days or it is normal.i have not taken any food or breakfast for at least more than two and half hours after taking medicine.my urine is also daily orange in colour UpTo evening.so please explain taking pills more than two glass of water make them ineffective as as iam little bit worry

Answered by Dr. Deepti Verma (1 hour later)

Brief Answer:
No decrease in effectivity

Detailed Answer:
Hi dear,
I have gone through your question and understand your concerns.
You can drink adequate water with the antitubercular tablet.
It has no effect on the efficacy of the pill. Tablet should be taken before breakfast for complete effectivity.
The urine is orange coloured due to the drug rifampicin which is excreted in the urine after being absorbed in the body,
You can drink as much water as you like after the tablet.
Hope you found the answer helpful.
Regards
Dr Deepti Verma

Above answer was peer-reviewed by : Dr. Kampana

Follow up: Dr. Deepti Verma (48 minutes later)

thank you madam for your prompt response...just worried that more water will make absorption of tablets long hence reduce their effectiveness.but as .my doctor suggested always maintained more than two hours gap between consumption of Akurit 3 tablets and breakfast

Answered by Dr. Deepti Verma (11 hours later)

Brief Answer:
no effect of the quantity of water on the absorption

Detailed Answer:
Hi dear,

There is no effect of the quantity of water on the absorption of antitubercular drugs or any other drug.
However, food affects absorption, hence the gap is advised between the drug and breakfast.

Regards
Dr Deepti Verma

Above answer was peer-reviewed by : Dr. Arnab Banerjee

Follow up: Dr. Deepti Verma (42 hours later)

madam sometimes within one and half hours of taking medicines the urine comes in orange colour after taking medicine with more water , is it OK or the absorption of pills are not sufficient.

Answered by Dr. Deepti Verma (14 hours later)

Brief Answer:
no relation with the absorption of the drug.

Detailed Answer:
Hi dear.
Orange colour of the urine is due to the drug excretion from kidney after the active part of the drug is absorbed in the body. It has no relation with the absorption of the drug.
Regards
Dr Deepti Verma

Above answer was peer-reviewed by : Dr. Nagamani Ng