Does Inhaled Corticosteroids Are Rarely Associated With Myopathy?

Question: hello

You ar positive doctor - and i hope for positive answer - as you can read and make stress of medicine literature

I have question it is said corticosteroide inhalers - they rare case murmule weakness

Inhaled corticosteroids are rarely associated with myopathy; if such myopathy occurs, it can be quickly reversed by interrupting the steroid treatment.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC0000/

And there is study about children - that it does not affect muscle function

No evidence was found that continuous high doses of inhaled steroids lead to a deterioration in respiratory or peripheral muscle function in asthmatic children
https://pubmed.ncbi.nlm.nih.gov/0000/


But in one study about older it is said

Conclusion: Chronic intake of inhaled corticosteroids induces clinically significant decrease of muscle functions at
least after 1-year of daily treatment

and there was comment that it occure in older generation

In our previous study we observed severe corticosteroid-induced
weakness and muscle atrophy in asthmatic patients aged N 70 years [23].
Indeed, sarcopenia and insufficient muscle metabolism are common
conditions in elderly people [24], and therefore corticosteroid effects
are especially unfavorable in elderly patients.

https://sci-hub.se/10.1016/j.jns.2013.12.023


So in case when corticosteroide inhalers case muscle weakness - you can change drug and treat this problem !

Thank you very much

Hello !

1.

What i have read that muscle problem affect old generation of inhaled corticosteroide - asthmatics
But children ar not effected - here is study

No evidence was found that continuous high doses of inhaled steroids lead to a deterioration in respiratory or peripheral muscle function in asthmatic children
https://pubmed.ncbi.nlm.nih.gov/0000/


It affect older asthmatic population because their muscle metabolic rate is decreasing - study

In our previous study we observed severe corticosteroid-induced
weakness and muscle atrophy in asthmatic patients aged N 70 years [23].
Indeed, sarcopenia and insufficient muscle metabolism are common
conditions in elderly people [24], and therefore corticosteroid effects
are especially unfavorable in elderly patients.

https://sci-hub.se/10.1016/j.jns.2013.12.023

as it said in literature

Treatment
Treatment of steroid-induced myopathy involves decreasing drug dosage or discontinuation. There is evidence of benefit of resistance exercises such as weight lifting.

https://www.sciencedirect.com/topics/nursing-and-health-professions/corticosteroid-induced-myopathy



So corticosteroids myopatia could be treated with reduce corticosteroids dose
And regular physical activity -
and young asthmatic generation who use inhaled corticoseroides is less affected because better muscle metabolic rate and ar more physical active !
Is seams logic !


2. So everyone who is using oral or inhaled corticosteroide should do regular exercise - to keep up muscle strength

As it said in literature it is base prophylactic for corticosteroid users -

3. And is said that -It severely affects less than 5% of patients
but respiratory muscles are rare involved - and again it is said that sport is important

physical exercise is a great way to prevent and treat corticoid-induced muscle damage.

https://cortisone-info.com/en/side-effects/side-effects-on-muscles-and-tendons/

So conclusion - respiratory functions are rare affected - and regular exercise is key to avoid muscle problems

Thank you very much