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Does Paliperidone Block All The Receptors That Aripiprazole Block? In
Question: Does paliperidone block all the receptors that aripiprazole block? In other words, is adding abilify useless if one is already taking invega? If a person who takes both invega and abilify suddenly stops taking abilify, would he or she relapse? Would he just suffer the withdrawals?
Brief Answer:
Different actions.
Detailed Answer:
Hello
Abilify and paliperidone have slightly different mechanism of actions.
If one is having poor response to one antipsychotic, second antipsychotic can be added to enhance the antipsychotic effect.
So adding abilify even when taking invega may not necessarily be useless. Rather it can be useful in case of poor responders.
Antipsychotic usually does not cause withdrawal symptoms. If there are any, it should usually resolve within a week of stopping the drug.
There can be a relapse even after stopping either of the two drugs.
Hope this answers your queries.
Thanks
Different actions.
Detailed Answer:
Hello
Abilify and paliperidone have slightly different mechanism of actions.
If one is having poor response to one antipsychotic, second antipsychotic can be added to enhance the antipsychotic effect.
So adding abilify even when taking invega may not necessarily be useless. Rather it can be useful in case of poor responders.
Antipsychotic usually does not cause withdrawal symptoms. If there are any, it should usually resolve within a week of stopping the drug.
There can be a relapse even after stopping either of the two drugs.
Hope this answers your queries.
Thanks
Above answer was peer-reviewed by :
Dr. Nagamani Ng
okay I thought that invega is a strong dopamine blocker and there is no clinical advantage in combining with abilify, a partial dopamine blocker. I heard that invega have more affinity to dopamine so about 80 to 90 percent, receptors will be blocked. If a patient who takes both invega and abilify stops abilify with a delusion that abilify is poison and invega isn't, would you say it would be more harmful than the one who thinks invega is poison? If you have to make a prediction, at what percent would that patient relapse?
Brief Answer:
Risk of relapse
Detailed Answer:
Stopping invega will cause relapse definitely.
But yes, stopping either of the drug increases risk of relapse.
There will be a relapse almost certainly but it's just a matter of time. Means, the time period between stooping of drug and relapse of symptoms can not be predicted.
Thanks.
Risk of relapse
Detailed Answer:
Stopping invega will cause relapse definitely.
But yes, stopping either of the drug increases risk of relapse.
There will be a relapse almost certainly but it's just a matter of time. Means, the time period between stooping of drug and relapse of symptoms can not be predicted.
Thanks.
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Above answer was peer-reviewed by :
Dr. Vaishalee Punj
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