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Does The Irregular Soft Tissue Sound Concerning?

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Posted on Tue, 20 Feb 2024
Question: I have Crohn’s Disease, which the physician’s assistant at my GI doctor’s office described as being in remission. I would like to try intermittent fasting and am wondering if this is a safe thing to do in your opinion. I have read mixed (mostly but not entirely) favorable views of intermittent fasting for people with Crohn’s Disease. I will definitely make sure I still get enough total calories. I have considered either time-restricted eating within each day or having occasional days when I don’t eat. I’m not sure if it’s relevant but I also have a bowel to bowel fistula that they did not seem worried about. I have pasted the full colonoscopy results below.

FINAL DIAGNOSIS: PART 1: TERMINAL ILEUM, EROSION, ENDOSCOPIC BIOPSY ACTIVE ILEITIS WITH VILLOUS BLUNTING (SEE COMMENT). PART 2: COLON, RANDOM, ENDOSCOPIC BIOPSY A. COLONIC MUCOSA WITH NO SPECIFIC PATHOLOGIC CHANGES. B. NO INCREASE IN THICKNESS OF SUBEPITHELIAL COLLAGEN LAYER ON TRICHROME STAIN. CAP/CAP COMMENT:
Part 1: The findings are non-specific regarding etiology. Clinical correlation is recommended to exclude the possibilities of inflammatory bowel disease.
GROSS DESCRIPTION: The specimen is received in 2 parts Part 1 (received in formalin) is labeled with the patient's name, initials LM, and as "erosion terminal ileum". SPECIMEN: 4 XXXXXXX irregular soft tissue fragments SIZE: 0.3 x 0.1 x 0.1 cm to 0.4 x 0.3 x 0.2 cm SECTION SUMMARY (entirely submitted): 1A Part 2 (received in formalin) is labeled with the patient's name, initials LM, and "random colon biopsies". SPECIMEN: Multiple XXXXXXX irregular soft tissue fragments SIZE: 0.2 x 0.1 x 0.1 cm to 0.4 x 0.2 x 0.1 cm SECTION SUMMARY (entirely submitted): 2A GROSSED BY: XXXXXXX T. XXXXXXX MLS, PA (ASCP) ATS//ATS/ATS MICROSCOPIC: Endoscopic images of the gastrointestinal tract were reviewed and correlated with histopathology. The significant findings of this endoscopic study are integrated into the above comprehensive final clinicopathologic diagnosis. Control slide for trichrome stain reacted appropriately. Microscopic examination substantiates the above diagnosis. The following statement applies to all immunohistochemistry, insitu hybridization (ISH & FISH), molecular & genomic pathology, and immunofluorescence testing: The testing was developed and its performance characteristics determined by the Department of Pathology, as required by the CLIA '88 regulations. The testing has not been cleared or approved for the specific use by the U.S. Food and Drug Administration, but the FDA has determined such approval is not necessary for clinical use. Tissue fixation ranges from a minimum of 6 to a maximum of 96 hours. Immunohistochemical stains (where applicable) are performed with appropriate positive and negative control reactions. Immunohistochemistry assays have not been validated on decalcified tissues. Results should be interpreted with caution given the raised possibility of false negativity on decalcified specimens. Methods of staining, performance characteristics, and validation assays of all antibodies in our test menu that are in clinical use are described in our laboratory test catalogue and readily available upon clinician, patient, or pathologist request. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ("CLIA") as qualified to perform high-complexity clinical testing. Pursuant to the requirements of CLIA, ASR's used in this laboratory have been established and verified for accuracy and precision. Additional information about this type of test is available upon request. PATIENT HISTORY: Chief Complaint/Surgery Pre-op Diagnosis: MELENA Surgery Post-op Diagnosis: ILEITIS Surgical Procedure: GI COLONOSCOPY W/BIOPSY SINGLE/MULTIPLE HISTO TISSUE SUMMARY/SLIDES REVIEWED: Part 1: 1 EROSION TERMINAL ILEUM Taken: 7/26/2023 11:16 Received: 7/26/2023 12:47 Stain/cnt Block x 2 A H&E L1,L2,L3 x 1 A Part 2: 2 RANDOM COLON BIOPSIES Taken: 7/26/2023 11:16 Received: 7/26/2023 12:47 Stain/cnt Block x 1 A x 1 A H&E L1,L2,L3 x 1 A Trichrome x 1 A CONSULTING PATHOLOGIST(S): XXXXXXX S. Nixdorf-Miller, M.D. TC1 UPMC Passavant Department of Pathology 9100 Babcock Boulevard XXXXXXX PA 15237
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Follow up: Dr. Ramesh Kumar (4 minutes later)
Also, does the "irregular soft tissue" sound concerning? They definitely didn't mention anything about cancerous growth, but I always worry about that.
doctor
Answered by Dr. Ramesh Kumar (10 hours later)
Brief Answer:
Please go through detailed answer.

Detailed Answer:
Hi and thanks for query,
If irregular soft tissue is there as per standard protocol a small sample of it is taken and is sent for biopsy(to be 100% sure of something wrong is not going on).
No doctor can say just by seeing if a tissue is cancerous/could be cancerous or is normal.
2)As far as intermittent fasting is concerned and as query has been asked in gastroenterology section(modern medicine), See modern medicine book(standard books which are read by doctors) don't mention intermittent fasting role in inflammatory bowel disease but yes intermittent fasting gives time for body to cleanse out and tissues get time to replete..So yes you could give it a try.
Please follow up for any other query or in case you have any doubt.
Regards!
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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Ramesh Kumar

Gastroenterologist

Practicing since :1986

Answered : 2913 Questions

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Does The Irregular Soft Tissue Sound Concerning?

Also, does the "irregular soft tissue" sound concerning? They definitely didn't mention anything about cancerous growth, but I always worry about that.