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Hello Dr. I Am Wondering If There Is A Substance

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Posted on Sun, 2 Jun 2019
Question: Hello Dr.

I am wondering if there is a substance that will slow the metabolism of trazodone or nefazodone. I am very sensitive to the effects of the mCPP metabolite And I have a mutated gene for 2d6 (I metabolized mCPP very slowly).

I am looking to maximize the affect of the parent drug in either case (5ht2 antagonism) whereas mCPP causes agitation in me. I also take modafinil, which speeds the metabolism of trazodone/nefazodone.

Thank you
doctor
Answered by Dr. Seikhoo Bishnoi (14 hours later)
Brief Answer:
The effect will not have clinical benefits.

Detailed Answer:
Hello thanks for using ask a doctor service

Trazodone is metabolised by multiple ways and one of this is by CYP3A4. Inhibitors of CYP3A4 can theoretically increase levels of Trazodone but I am afraid this would not be very useful clinically.

Antibiotics like erythromycin, clarithromycin etc, ketoconazole, grapefruit etc are inhibitors. But should not be used clinically to increase the effects.

Thanks.
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Above answer was peer-reviewed by : Dr. Vaishalee Punj
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Answered by
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Dr. Seikhoo Bishnoi

Psychiatrist

Practicing since :2007

Answered : 5192 Questions

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Hello Dr. I Am Wondering If There Is A Substance

Brief Answer: The effect will not have clinical benefits. Detailed Answer: Hello thanks for using ask a doctor service Trazodone is metabolised by multiple ways and one of this is by CYP3A4. Inhibitors of CYP3A4 can theoretically increase levels of Trazodone but I am afraid this would not be very useful clinically. Antibiotics like erythromycin, clarithromycin etc, ketoconazole, grapefruit etc are inhibitors. But should not be used clinically to increase the effects. Thanks.