Question: Hello, I need reassurance. I have bad health anxiety and I'm scared I may have peutz-jeghers syndrome. I have a brown labial macule since childhood and a few macules scattered across my pubic/anal area (medium to light brown). However I never had fingers/foot/inner mouth macules. I also underwent a couple abdominal ct scans (with and without contrast) + an upper endoscopy combined with a colonoscopy at age 24 (to investigate diarrhea and cramping, i'm 28 now with IBS and Hashimoto's otherwise healthy female) that showed absolutely no polyps. My dermatologist tells me my spots are not Peutz-jeghers' at all and that I should relax. Should I specifically ask for a jejunum screening or am I clear ? I guess if there have been any polyp linked to this disease it should have showed up by age 24 ?Thanks for your insight.

Thanks for answering, Dr Asmeet

Can those macules be a simple feature without an associated syndrome then ?
I also have 3 cafe au lait spots on the right side of my body (right knee, right hip and right buttock, there are pale and a bit irregular). Most people on my maternal side exhibit a cafe au lait spot including my mother, aunt and uncle, and my mother has intensive body freckling.

My maternal grandmother died of cancer in her 60's (unknown cancer type since it was found too late to track back its primary source) but otherwise there's no malignancy history in my family.

I have between 7-9 XXXXXXX tiny spots/lentigines around my pubis (mostly on the mons pubis and a couple near my labia), two around the anal verge, and only one on my face (lower lip vermillion) + freckling mostly on the right side of my body (right arm and right knee, there is one cafe au lait spot on that exact knee)

Does it make you think of a syndrome in particular or is it just an unique pigmentation ?

I underwent the following (clear) health exams also :
-clear brain MRI
-clear spinal x-ray save for a very mild scoliosis
-clear chest x-ray
-clear abdominal ultrasounds
-clear pelvic ultrasounds
-clear breasts ultrasound

I guess if anything was wrong it would have been noticed during childhood but I'm wondering why I'm exhibiting all those cutaneous features. I was thinking about Cowden and XXXXXXX Complex but except for my skin there is nothing that matches perfectly.

Thank you for your professional opinion.