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Hello Doctor I Am Asking The Question For My Mother
Question: Hello doctor
I am asking the question for my mother ..
69 years old . Healthy and taking hypertension medication concor and taking aspirin daily.
Actually I am a pharmacist and lately she had blood tests done and her HB was 17 and Platelet 680 and WBC 8.9 . Local doctor told us that she should do JAK2 mutation test and she did it and tested positive for jak 2 with ratio 16.5% . A local doctor here told us that with high number of platelet if JAK 2 is negative , then she should do further tests and if it is positive, then it's a good point. So now the JAK 2 is positive with 16.5 % and with her above lab findings , How can we bring her HB and Platelet down ?
I appreciate your response.
Thanks
I am asking the question for my mother ..
69 years old . Healthy and taking hypertension medication concor and taking aspirin daily.
Actually I am a pharmacist and lately she had blood tests done and her HB was 17 and Platelet 680 and WBC 8.9 . Local doctor told us that she should do JAK2 mutation test and she did it and tested positive for jak 2 with ratio 16.5% . A local doctor here told us that with high number of platelet if JAK 2 is negative , then she should do further tests and if it is positive, then it's a good point. So now the JAK 2 is positive with 16.5 % and with her above lab findings , How can we bring her HB and Platelet down ?
I appreciate your response.
Thanks
Also just to let you know doctor she has normal differential WBC and normal ESR
Brief Answer:
periodic phlebotomy and aspirin
Detailed Answer:
Hi
Thanks for your query.
The diagnosis in her case is polycythemia vera. The primary treatment is periodic letting out of blood (phlebotomy) to keep hematocrit below 45. This helps to reduce thrombosis risks. Along with this, low dose aspirin should be continued.
If platelet counts continue to increase then hydroxyurea can be given to bring it down.
Hope this helps.
Regards
periodic phlebotomy and aspirin
Detailed Answer:
Hi
Thanks for your query.
The diagnosis in her case is polycythemia vera. The primary treatment is periodic letting out of blood (phlebotomy) to keep hematocrit below 45. This helps to reduce thrombosis risks. Along with this, low dose aspirin should be continued.
If platelet counts continue to increase then hydroxyurea can be given to bring it down.
Hope this helps.
Regards
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Thanks for your reply doctor.
For how many times should she do the phlebotomy? Like once weakly ?
And if hydroxy urea required what will be the dose ?
Thanks
For how many times should she do the phlebotomy? Like once weakly ?
And if hydroxy urea required what will be the dose ?
Thanks
Brief Answer:
Frequency varies
Detailed Answer:
Phlebotomy frequency is variable, whatever required to achieve hematocrit goal. Once a week is a good starting point. May reduce later.
Hydroxyurea starting dose is usually 1.5 gm per day. Again, dose varies.
Regards
Frequency varies
Detailed Answer:
Phlebotomy frequency is variable, whatever required to achieve hematocrit goal. Once a week is a good starting point. May reduce later.
Hydroxyurea starting dose is usually 1.5 gm per day. Again, dose varies.
Regards
Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now
Above answer was peer-reviewed by :
Dr. Arnab Banerjee
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