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Hi, I Had Two Blood Test Come Back With High
Question: Hi, I had two blood test come back with high elevated levels of IGF-1 and IGFBP3. The dr did a hormone suppression test and said I Shpresa nicely. What can be other causes for this?
i meant to say he supressed nicely with the hormone suppression test.
Brief Answer:
Pituitary tumor.
Detailed Answer:
Hello
I have gone through your query and understood your concern.
High levels of circulating insulin-like growth factor-1 (IGF-1) and IGF-1 binding protein 3 (IGFBP-3) indicate a sustained overproduction of GH caused mostly by GH-secreting pituitary adenomas,/
Other potential causes for high IGF1 levels are low thyroid hormone levels. Liver disease. Uncontrolled diabetes mellitus , cardiovascular disease or intense exercises.
For the diagnosis of acromegalia a single random GH and IGF1 test is not enough to conclude the diagnosis because growth hormone or IGF1 are normally released in pulses and random levels vary widely.
It is also necessary to do an oral glucose tolerance test (OGTT) or hormone suppresion test.
If your GH and IGF1level doesn't drop to below 1 ng/mL during the OGTT, you have acromegaly.
Your GH level should respond to so much glucose by dropping, so if it doesn't, that tells the doctor that your body isn't listening to its own signals: The delicate feedback loop of the endocrine system has been disturbed.
Please upload the oral glucose tolerance test result ,because it is necessary to see the exact result to deduce the right diagnosis.
Waiting your reply.
Regards
Pituitary tumor.
Detailed Answer:
Hello
I have gone through your query and understood your concern.
High levels of circulating insulin-like growth factor-1 (IGF-1) and IGF-1 binding protein 3 (IGFBP-3) indicate a sustained overproduction of GH caused mostly by GH-secreting pituitary adenomas,/
Other potential causes for high IGF1 levels are low thyroid hormone levels. Liver disease. Uncontrolled diabetes mellitus , cardiovascular disease or intense exercises.
For the diagnosis of acromegalia a single random GH and IGF1 test is not enough to conclude the diagnosis because growth hormone or IGF1 are normally released in pulses and random levels vary widely.
It is also necessary to do an oral glucose tolerance test (OGTT) or hormone suppresion test.
If your GH and IGF1level doesn't drop to below 1 ng/mL during the OGTT, you have acromegaly.
Your GH level should respond to so much glucose by dropping, so if it doesn't, that tells the doctor that your body isn't listening to its own signals: The delicate feedback loop of the endocrine system has been disturbed.
Please upload the oral glucose tolerance test result ,because it is necessary to see the exact result to deduce the right diagnosis.
Waiting your reply.
Regards
Above answer was peer-reviewed by :
Dr. Yogesh D
would liver disease show up on routine labs?
Brief Answer:
Routine labs can show liver diseases.
Detailed Answer:
Hi again.
I appologise for the late reply.
If he has a pituitary lesion and high GH/IGF1levels,it can be a correlation.
If the tumor is <10mm it is called microadenoma.
Even a small microadenoma can produce pituitary hormones and cause symptoms.
Routine labs can show liver diseases.
Detailed Answer:
Hi again.
I appologise for the late reply.
If he has a pituitary lesion and high GH/IGF1levels,it can be a correlation.
If the tumor is <10mm it is called microadenoma.
Even a small microadenoma can produce pituitary hormones and cause symptoms.
Note: For more information on hormonal imbalance symptoms or unmanaged diabetes with other comorbid conditions, get back to us & Consult with an Endocrinologist. Click here to book an appointment.
Above answer was peer-reviewed by :
Dr. Prasad
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