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How Effective Is Systemic Chemotherapy For Metastatic Colorectal Cancer?
Question: How effective is chemo is metastic colon cancer ?
Brief Answer:
Chemotherapy response is very individual thing.
Detailed Answer:
Hello!
Thank you for the query.
Can you please give some more details about the cancer? Where are the metastases located? Is it single metastasis or multiply? Was there KRAS mutation checked?
Chemotherapy sensitivity is a very individual thing. Every cancer is build of different cells so there can be very different response for chemotherapy. For sure, nowadays, chemotherapy can not cure metastatic colon cancer. But it can greatly extend life.
For sure chemotherapy should be associated with Bevacizumab (Avastin). This is an antibody which is targeted to cancer cells. We call it target therapy. The effectiveness of classic chemotherapy with Bevacizumab is much higher than chemotherapy alone.
Once again, chemotherapy response is individual. And no one can tell how much life will be gained with such treatment.
Hope this will help. Feel free to ask further questions.
Regards.
Chemotherapy response is very individual thing.
Detailed Answer:
Hello!
Thank you for the query.
Can you please give some more details about the cancer? Where are the metastases located? Is it single metastasis or multiply? Was there KRAS mutation checked?
Chemotherapy sensitivity is a very individual thing. Every cancer is build of different cells so there can be very different response for chemotherapy. For sure, nowadays, chemotherapy can not cure metastatic colon cancer. But it can greatly extend life.
For sure chemotherapy should be associated with Bevacizumab (Avastin). This is an antibody which is targeted to cancer cells. We call it target therapy. The effectiveness of classic chemotherapy with Bevacizumab is much higher than chemotherapy alone.
Once again, chemotherapy response is individual. And no one can tell how much life will be gained with such treatment.
Hope this will help. Feel free to ask further questions.
Regards.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Brief Answer:
Avasting is a very good idea.
Detailed Answer:
If you are able to add Avastin, this is a very good idea. Like I have said before, it can greatly extend his life. KRAS mutation should be ruled out before adding it.
Yes, he may have eating problems. Chemo is affecting intestinal cells. This is very common thing.
He may also try radioembolisation if liver mets after finishing chemo.
Regards.
Avasting is a very good idea.
Detailed Answer:
If you are able to add Avastin, this is a very good idea. Like I have said before, it can greatly extend his life. KRAS mutation should be ruled out before adding it.
Yes, he may have eating problems. Chemo is affecting intestinal cells. This is very common thing.
He may also try radioembolisation if liver mets after finishing chemo.
Regards.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Ya I spoken to
You . We are worried worried as since first session lost 3 kg and hates good only eats bit.
He's KRAS mutant
The regime they are giving is oxy and ralititrexed . Can avastin be added to this particular regime ?
Also as he has 4 peritoneal
Nodules they said no to radio embolization too
You . We are worried worried as since first session lost 3 kg and hates good only eats bit.
He's KRAS mutant
The regime they are giving is oxy and ralititrexed . Can avastin be added to this particular regime ?
Also as he has 4 peritoneal
Nodules they said no to radio embolization too
Brief Answer:
Yes Avastin can be added to this chemo.
Detailed Answer:
Yes, avastin ca be added to this type of chemo. Even with KRAS mutatio it should be tried. He will be loosing weight as long as chemo will be given. Steroids can help with an apettite.
Regards.
Yes Avastin can be added to this chemo.
Detailed Answer:
Yes, avastin ca be added to this type of chemo. Even with KRAS mutatio it should be tried. He will be loosing weight as long as chemo will be given. Steroids can help with an apettite.
Regards.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Can avastin work with KRAS mutatin ? I'm sure I read it can .
Can the cancer be resistant to avastin too ?
With irinotecan he had hardly no effects n that failed . But with this oxy n raltitrexed it's knocked him for 6!
Is this a good chemo combo ?
Can the cancer be resistant to avastin too ?
With irinotecan he had hardly no effects n that failed . But with this oxy n raltitrexed it's knocked him for 6!
Is this a good chemo combo ?
Brief Answer:
Avastin should be tried even with this mutation.
Detailed Answer:
Yes, it still can work with this mutation. Its worth to try.
Yes, it can be resistant to avastin as well. It attacks specific cells receptors. In case of lack of this receptors on cancer cells, it wont work.
If the metastases has shrink this is a good chemo. It should be checked with CT. That how we find it the chemo response.
Regards.
Avastin should be tried even with this mutation.
Detailed Answer:
Yes, it still can work with this mutation. Its worth to try.
Yes, it can be resistant to avastin as well. It attacks specific cells receptors. In case of lack of this receptors on cancer cells, it wont work.
If the metastases has shrink this is a good chemo. It should be checked with CT. That how we find it the chemo response.
Regards.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Brief Answer:
If chemo wont work nothing more can be done.
Detailed Answer:
If chemo wont work, nothing else can be done. Thats the main problem of modern medicine. That is why cancer is so serious disease.
Yes 30 liver mets are possible. Whole liver can be covered with mets.
If chemo wont work nothing more can be done.
Detailed Answer:
If chemo wont work, nothing else can be done. Thats the main problem of modern medicine. That is why cancer is so serious disease.
Yes 30 liver mets are possible. Whole liver can be covered with mets.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
If there's about 9-10 mets this mean whole liver covered ? 2 mets are 7 cm rest smaller.
Is peritoneal area more worse or liver ?
Is peritoneal area more worse or liver ?
Brief Answer:
Liver can be covered with mets indeed.
Detailed Answer:
10 mets is still a lot. So most likely whole liver is affected. Liver mets is the worst location. Much worse than peritoneal.
You need to wait and see how chemo will work.
Liver can be covered with mets indeed.
Detailed Answer:
10 mets is still a lot. So most likely whole liver is affected. Liver mets is the worst location. Much worse than peritoneal.
You need to wait and see how chemo will work.
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Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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