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How Is The Mutation Status Of The KRAS Gene Detected?

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Posted on Thu, 5 Jan 2017
Question: What percentage of tumor cells from a biopsy are needed to accuratly assess KRAS mutation in colon cancer?
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Answered by Dr. Indranil Ghosh (1 hour later)
Brief Answer:
At least 10%

Detailed Answer:
Hi
Thanks for your query.

At least 10% of tumor cells in the biopsy is required. And two biopsy cores of 1 cm each with more than 10% tumor cells should be enough to generate DNA to do the test.

Hope this helps.
Regards
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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Indranil Ghosh

Oncologist

Practicing since :2004

Answered : 1712 Questions

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How Is The Mutation Status Of The KRAS Gene Detected?

Brief Answer: At least 10% Detailed Answer: Hi Thanks for your query. At least 10% of tumor cells in the biopsy is required. And two biopsy cores of 1 cm each with more than 10% tumor cells should be enough to generate DNA to do the test. Hope this helps. Regards