Brief Answer: citalopram generally takes 2-3 weeks to act Detailed Answer: Hello, Please donot worry, I will try to help you. 1. Diazepam is not an antidepressant or antimanic drug. It is a benzodiazapine drug used in bipolar and other psychiatric disorders to improve sleep/ agitation/ anxiety issues. So, it is used as per the need of the hour. Its use is preffered to be short as it has addiction potential and gradually loses effect over time and more drug is needed. 2. Citalopram takes 2-3 weeks on an average to show results in patients. So, we generally wait for this much time before hiking the dose. 3. Looking at her comorbidities, I think sertraline will be a better drug for her. It is cardio safe and a mild molecule. If your wife is taking diazepam in daytime or taking a high dose of diazepam at night- the fall could be related to its sedative effect. I have tried to provide you the facts related to the situation. Now should discuss the points with her trating team. Wish you good health. Please feel free to ask more question for clarification. Dr. Manisha Gopal MD Psychiatry

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