How Significant Are The Absolute And Relative Nucleated Red Blood

Posted on Sun, 12 Jan 2020

Question: How significant are the absolute and relative nucleated red blood cell counts in management of sickle cell crisis? Do they influence treatment decisions?

Answered by Dr. Indranil Ghosh (1 hour later)

Brief Answer:
Not usually

Detailed Answer:
Hi
Thanks for your query.

Nucleated RBCs signify hemolysis. They have no role in pathogenesis of sickle cell crisis, which is due wedging of capillaries by sickle cells.

Hence we need not target them in management of sickle cell crisis.

Hope this helps.
Regards

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Above answer was peer-reviewed by : Dr. Vaishalee Punj