I Am 38 Years Old , With Irregular Periods The Ultrasound Show That The Fetus Was 5 Weeks . Injection Of Amikacin Does Harm My Baby , I Have Read That The Bactrim Is A Antifolate Medicine ?

Posted on Sun, 26 Feb 2023

Question: I am 38 years old , my beginning of my last menstruation was XXXXXXX 22, I take trimethropim sulfamethoxazole 160/800 mg from July 19 to July 25, one pill each 12 hours , one injection of amikacin in July 19 . Because my menstruation is irregular , In August 7, the ultrasound show that the fetus was 5 weeks .

I am worried about that the medicine does harm my baby , I have read that the Bactrim is a antifolate medicine . What will be the risk in my case .

Answered by Dr. Richa Agarwal (1 hour later)

Brief Answer:
It is better not to use this drug during first trimester of pregnancy.

Detailed Answer:
Hello,
I have gone through your history and understand your concern.
It is true that these medicines mechanisms of action used inhibition of folic acid production and it may cause congenital malformations ( neural tube defects) during pregnancy but if during pregnancy folic acid levels are appropriate and used for short period of time,may not foetal congenital abnormalities.
So you have to take folic acid in higher dose and get your foetus detailed study( second level ultrasound) for foetal well being.
Hope found useful,feel free to ask more information.
Good luck
Regards.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar