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I Am A Male, 35 Years Old, 220 Lbs, Non-smoker,

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Posted on Tue, 29 Sep 2020
Question: I am a male, 35 years old, 220 lbs, non-smoker, don't live at high altitude and no lung conditions.
About 5 years ago, routine bloodwork came back that showed me hematocrit slightly elevated at 51% (ref. range 41-50). My doctor wasn't concerned but I looked at my past blood work and most of the time, my hematocrit was in the 46-48% range. I had a repeat test and my hematocrit was 52%, RBC 5.8 and hemoglobin 17.5 -- all slightly elevated again.
My doctor wasn't concerned but I took it upon myself to see a hematologist. I took my records the hematologist and he said "this does not seem like polycythemia vera but I will test for it to just cover all the bases." He did a repeat CBC, an EPO serum test, a genetic JAK2 mutation test, a JAK2 exon 12 test, and a CALC mutation test.
The EPO serum came back normal at 7 ( reference range: 4 - 27) and all the mutations came back as negative. The CBC did show my hematocrit at 53%, hemoglobin at 18 and RBC at 5.9 though. He said if I wanted assurance, he could order a Red Blood Cell Mass test which is a long test of blood draws that separates the plasma and measures the red blood cell mass... and only a few locations do it. Luckily, there was a hospital by me in NYC that did it. That test came back as "normal red blood cell mass" .
He told me "just do a repeat EPO and repeat CBC in 6 months and make sure you really hydrate during that time". I spent the next 6 months drinking more water than I ever have. When I took the test at the 6 month mark, my EPO was 10 (normal again) and this time, my hematocrit was normal (47%) , hemoglobin normal (16.5) and RBC normal (5.2). He called and said "that is what I like to see. No need to come back."

That was 5 years ago and since then, I've had routine blood tests for other reasons (physicals, etc) and the majority of them all have the same elevated hematocrit, hemoglobin and RBC. I have 2 or 3 scattered time over the years where they come back in the normal range but most of the time, they are elevated. I just had one last week and it came back at hematocrit 53% , hemoglobin 18% and RBC 5.9.
Am I missing something? Could my doctor have missed something?
doctor
Answered by Dr. Shailja Puri (51 minutes later)
Brief Answer:
All investigations within the normal range, nothing to worry.

Detailed Answer:
Hello,
Thanks for posting your query on 'Ask A Doctor' forum.

Your doctor has ordered all investigations to rule out the possibility of polycythemia vera which is a genetic disorder.

The mutations JaK 2 and CALR mutations are negative, thus, there is nothing to worry about.
You can get your routine investigations yearly and if possible erythropoietin (EPO) yearly.

Rest, you can relax, there is nothing to worry about.

Thanks and take care
Dr. Shailja Puri


Above answer was peer-reviewed by : Dr. Arnab Banerjee
doctor
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Follow up: Dr. Shailja Puri (38 minutes later)
Thank you, Dr. Puri. One question that I never really had answered was can hydration "mask" polycythemia vera? Could drinking more water than I normally do have artificially lowered my red blood numbers, thus masking PV?
I'm just curious as to why I have elevated numbers if there is no clear cause. Thanks again.
doctor
Answered by Dr. Shailja Puri (13 hours later)
Brief Answer:
Inadequate hydration can lead to spurious rise in red cell mass.

Detailed Answer:
Hello and welcome again,
Hydration is not related to polycthemia vera (PV).
Secondary polycthemia can occur if there is inadequate hydration in body.
Reduction in water content in body can lead to spurious increase in red call mass.
You were told to maintain adequate hydration to avoid spurious rise in red cell mass.
I hope I have cleared your doubt.

Thanks and take care
Dr Shailja Puri
Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now

Above answer was peer-reviewed by : Dr. Nagamani Ng
doctor
Answered by
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Dr. Shailja Puri

Pathologist and Microbiologist

Practicing since :2006

Answered : 9705 Questions

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I Am A Male, 35 Years Old, 220 Lbs, Non-smoker,

Brief Answer: All investigations within the normal range, nothing to worry. Detailed Answer: Hello, Thanks for posting your query on 'Ask A Doctor' forum. Your doctor has ordered all investigations to rule out the possibility of polycythemia vera which is a genetic disorder. The mutations JaK 2 and CALR mutations are negative, thus, there is nothing to worry about. You can get your routine investigations yearly and if possible erythropoietin (EPO) yearly. Rest, you can relax, there is nothing to worry about. Thanks and take care Dr. Shailja Puri