
I Had Depression/ Anxiety For 16 Years. About Ten Years

Stimulant medications.
Detailed Answer:
Hello
Welcome here.
I have gone through your details.
You feel that you have moderate to severe depression. And the main problem you are facing at present is increased sleepiness.
Yes, there are neurochemicals which are implicated in causing depression. The major ones are serotonin, nor-epinephrine and dopamine. The imbalance or deficiency of one or more of these can cause depression.
16 years is a long time and you have for such long period. In such cases, if the antidepressants does not show satisfactory response,(possibly resistant depression), ketamine should be considered. It can show immediate benefits. The effect however may be short lasting but it definitely help. Antidepressants can be continued after that.
Another option is stimulating medications like methylphenidate or atomoxetine or modafinil. These should however be used for short term only.
Please discuss these options with your treating doctor and proceed accordingly.
All the best.
Thanks.

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