
I Have High Lipase (108) And Eosiniphils (6.4%) And I

At the end of Feb. 2019, after feeling cruddy for a few day and then having severe lower back pain, I went to the ER to find out my my kidneys were not functioning properly (eGFR of 55) and my lipase levels were slightly elevated (53). No stones, no virus, and no infections were appeared to be present. CT showed inflammation of kidneys but all other organs were unremarkable. I have had no prior kidney issues and they have since returned to normal function without medication. I am 29yo, Caucasian male, 5' 10", 215lb.
Since the ER visit, I have had days where I've felt perfectly fine and I've had days where I've felt cruddy. I've had some joint and bone pain but nowhere specific or reoccurring.
In the fall of 18 I was having some gut issues - bloating, diarrhea, excessive gas, etc. Did blood work, stool samples, and had a colonoscopy but that all came back perfect. I was under a high amount stress so it was ultimately attributed to that.
So I guess my main question is who do I turn to for the best advice as I don't feel GI is the direction since I've recently gone through a handful of GI tests.
metabolic syndrome,allergy,chronic inflammation possible.
Detailed Answer:
Hello and welcome to Ask A Doctor services.
I have read your query and here is my advise.
* As per my surgical experience, various conditions can contribute to the raised levels of
Lipase and Eosinophils as metabolic syndromes, allergy, chronic inflammation and
others.
* Many lab consider a value of 85 and even upto 106 of Lipase to be normal reference
range and yours does not sound that high of 108.
Kindly provide me further details so that I can answer your query completely because the reports are only supportive measures, the main importance is clinical context.
1. What are your current complains, please give all details.
2. The mentioned weight of 215 lb has any alteration in recent time ?
3. If other reports available, attachment is appreciated in follow up.
Wish you great day.
Awaiting for your response.
Dr Bhagyesh ( MS consultant surgeon )


My current complaints:
Some days I feel great other days I feel generally unwell. Nothing specific as far as nausea, vomiting, fever, etc. I'm not sure how to explain it except to say that I feel unwell and drained of energy.
4/12 - 4/15 I felt unwell and had some lower back pain so I called my doctor and he ordered a creatinine test to see if kidney function had fallen again. It tested fine on 4/15 and by 4/16 I was feeling normal again. In the midst of feeling unwell during those days, I woke up on 4/14 with severe chest pain, not sharp, more dull-feeling, that lasted for approximately 5 minutes. I had not had any chest pain prior or since.
4/16 - 4/19 I felt fine.
4/20 I woke up with pain in, what feels like, the middle of my left femur. It comes and goes quickly. It has been inconsistent but somewhat recurring. When the pain comes on, it's strong, but only lasts for a second or two. As I am typing this it has actually happened a couple of times.
Aside from some random pains throughout my body, mostly arms, legs, and joints, that, like my femur pain, comes and goes quickly, I have felt great since 4/20.
I scheduled with my PCP to try to get to the bottom of what caused the kidney issues in the first place so that's when more tests were ordered and found Lipase at 108 and Eosinophils at 6.4%. I got the test results today and they said they will refer me to GI.
Weight:
I weight has fluctuated between 200 and 220 over the past year.
When I went to the ER my weight was 218. I had been working behind a desk almost everyday and my diet had been poor for quite some time. I work 10 hour days and then work on remodeling a house until bedtime. So I eat on the go and, at that time, didn't get much exercise. My role at work has changed and I am working in a warehouse doing very physically demanding work so I am getting plenty of exercise now. My current weight is 206 (4/24). I have been working physically since March 7. I have also tried to improve my diet some since the ER visit. So I have attributed the weight loss to getting plenty of exercise and eating healthier than before.
When they ordered the most recent blood work, the did the following tests:
Comprehensive Metabolic Panel
CBC w/ Differential
C-Reactive Protein
Lipase
Sedimentation Rate
Urinalysis
Everything else in these tests came back normal.
I have felt "off" since XXXXXXX 2018. I had a partial tear in my esophagus which caused me great anxiety and stress - on top of my elevated stress of working and remodeling a house. So I had been to my PCP multiple times looking for answers as to why I didn't feel healthy. They ordered a slew of tests and everything came back perfectly normal except for ANA.
Almost a year ago to the day, I tested positive for ANA (homogeneous pattern) Positive Titer - 1:40.
Because of this I was referred to a Rhuemetologist and was (very quickly) looked over without additional testing. The Rhuemetologist thought it was most likely a false positive based on a clean XXXXXXX of health otherwise and not having any inflammatory issues in the past.
Lastly, below is a copy of the CT scan results from my ER visit on 2/27 when I went in for lower back pain and found kidney issues.
EXAM: CT Abdomen and Pelvis without IV contrast
INDICATION: Flank pain, stone disease suspected, right flank pain radiating to the left flank
TECHNIQUE: Multi-detector row images were acquired from the lung bases through the ischial tuberosities without the use of IV contrast. Sagittal and coronal images were acquired from the transaxial data. All CT scans performed at this facility utilize
dose optimization techniques as appropriate to the exam, including the following: Automated exposure control and adjustment of the mA and/or KV according to patient size (this includes techniques or standardized protocols for targeted exams where dose is
indication/reason for exam).
ORAL CONTRAST: None
DLP: 617 mGycm
COMPARISON: MRI enterography 06/25/2018
FINDINGS:
Evaluation limited in the absence of IV contrast which includes the viscera and vasculature.
Calcified granulomas in the right lung bases. Cluster of tiny noncalcified nodules surrounding a calcified granuloma in the right lower lobe compatible with tiny noncalcified granulomas. Heart size is normal.
The liver and spleen are normal in size. The gallbladder is nondistended. No radiopaque gallstones or significant biliary ductal dilatation. The pancreas and adrenal glands are grossly unremarkable.
There is mild right perinephric and periureteral fat stranding without hydronephrosis. No nephrolithiasis or ureteral calculi identified. No left hydronephrosis.
Small and large bowel loops are normal in caliber without evidence of obstruction. Fatty infiltration of the appendix which is otherwise unremarkable. Organized contents within several nondilated small bowel loops within the lower abdomen which may
represent partially digested food bolus or slowed intestinal transit. No ascites, significant lymphadenopathy, or pneumoperitoneum. The abdominal aorta and iliac arteries are normal in caliber.
Tiny fat containing umbilical hernia. Urinary bladder is incompletely distended with mild circumferential wall thickening. The prostate is normal in size. Small fat containing bilateral inguinal hernias, larger on the left. No destructive osseous lesions
are identified.
IMPRESSION:
IMPRESSION:
1. Mild urinary bladder wall thickening which may be due to incomplete distention or cystitis. Mild right perinephric and periureteral fat stranding without hydronephrosis or nephrolithiasis, nonspecific though possibly due to ascending UTI and
pyelonephritis. Clinical and laboratory correlation recommended.
2. No ascites or bowel obstruction. Normal appendix.
Thank you for your time,
Isaac Tarwater
follow up .
Detailed Answer:
Hi
Thanks for the all relevant details.
* As per the details, there can be possible metabolic alteration of some extent
responsible for combined GI and renal show up.
* The CT report with calcified granuloma in right lower lobe of lung most likely reflect
high Eosinophils ; whether chest CT or other work up considered for finding the reason
of the same ? ( As there was ANA titre of 1:40 a year back as per your history,
possibility of auto immune disorder can not be denied ).
* It is the sequence raising of lab parameter of more clinical importance rather than a
single lab finding.
* My suggestions at present
- Maintain hydration with more liquids.
- Manage balanced nutritious diet with avoidance of excess dairy fat, cheese, junk foods.
- Continue exercises as already you are doing fine.
- Avoid smoking or alcohol ( if consuming ).
- Try to manage sound regular sleep of 7 hours.
- Avoid stress and anxiety which are major provoking factors to disturb metabolic profile.
- Regular meditations and dedicated YOGA practice will help the issue to unbelievable
levels over period of time.
* No immediate reference to gastro is warranted, however, a repeat test of Lipase and
Eosinophils is recommended after a period of 3 weeks, once the above is followed
precisely.
Wish this information will help you for sure.
Wish you great health.
Regards.

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