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I Have Severe Pain (inflammation )in My Replaced Knees. Nasaids

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Posted on Wed, 18 Mar 2020
Question: I have severe pain (inflammation )in my replaced knees. Nasaids like Alleve or ibuprofin work 95% for about 12 hours. However, my doc says, that because I'm taking warfarin, I should NEVER take Alleve or similar. What's your opinion?
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Answered by Dr. Aaron Branch (45 minutes later)
Brief Answer:
There is a minor interaction

Detailed Answer:
Hello, I'm Dr. Branch, thanks for using 'Ask A Doctor' service.

There is an interaction between warfarin and anti-inflammatories like Ibuprofen and Aleve that can increase the risk for bleeding, which sometimes can be serious.

Different doctors may have different opinions on how much risk there actually is with using both of these medications together. I would normally assess how much benefit a patient can get from using anti-inflammatories, and try to determine if it would be worth the (probably) small risk of bleeding.

If there were any other options for treating your knee pain (such as steroid injections, or anti-inflammatory gel that can be applied to the knees), I would try those first as well.

So, I would discuss these options with your doctor, letting them know how much pain relief you are getting with the anti-inflammatory medications, and see if they think it might be worth the risk.

I hope that helps, please let me know if you have any other questions, I would be glad to discuss it with you further.

Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by : Dr. Arnab Banerjee
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Answered by
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Dr. Aaron Branch

General & Family Physician

Practicing since :2011

Answered : 1202 Questions

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I Have Severe Pain (inflammation )in My Replaced Knees. Nasaids

Brief Answer: There is a minor interaction Detailed Answer: Hello, I'm Dr. Branch, thanks for using 'Ask A Doctor' service. There is an interaction between warfarin and anti-inflammatories like Ibuprofen and Aleve that can increase the risk for bleeding, which sometimes can be serious. Different doctors may have different opinions on how much risk there actually is with using both of these medications together. I would normally assess how much benefit a patient can get from using anti-inflammatories, and try to determine if it would be worth the (probably) small risk of bleeding. If there were any other options for treating your knee pain (such as steroid injections, or anti-inflammatory gel that can be applied to the knees), I would try those first as well. So, I would discuss these options with your doctor, letting them know how much pain relief you are getting with the anti-inflammatory medications, and see if they think it might be worth the risk. I hope that helps, please let me know if you have any other questions, I would be glad to discuss it with you further.