
I Have Severe Pain (inflammation )in My Replaced Knees. Nasaids

There is a minor interaction
Detailed Answer:
Hello, I'm Dr. Branch, thanks for using 'Ask A Doctor' service.
There is an interaction between warfarin and anti-inflammatories like Ibuprofen and Aleve that can increase the risk for bleeding, which sometimes can be serious.
Different doctors may have different opinions on how much risk there actually is with using both of these medications together. I would normally assess how much benefit a patient can get from using anti-inflammatories, and try to determine if it would be worth the (probably) small risk of bleeding.
If there were any other options for treating your knee pain (such as steroid injections, or anti-inflammatory gel that can be applied to the knees), I would try those first as well.
So, I would discuss these options with your doctor, letting them know how much pain relief you are getting with the anti-inflammatory medications, and see if they think it might be worth the risk.
I hope that helps, please let me know if you have any other questions, I would be glad to discuss it with you further.

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