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I Would Like To Know If Isotretinoin Is Metabolized Via
Question: I would like to know if isotretinoin is metabolized via CYP450? If I am a poor metabolizer will this medicine be okay for me to take? How often/what percent of the severe side effects occur?
Brief Answer:
Isotretinoin is given for severe case of recalcitrant nodulocystic acne
Detailed Answer:
Hello and welcome to Ask A Doctor service.
I have reviewed your query and here is my advice.
I will suggest to try all other options including systemic antibiotics before trying isotretinoin especially in young age.
Skin and mucous membrane related side effects occur in almost all patients taking this medicine. Hypersensitivity reactions, pancreatitis, hepatotoxicity, hearing impairment, inflammatory bowel disease may happen. It may also affect the bones, spine and the lipid profile.
After absorption, it produces 3 metabolites. There are some studies to suggest that it gets metabolised by CYP450. One of the metabolites is suggested to be more active than the parent compound. So, if you are poor metaboliser then the side effects will be more.
Hope this answers your query. Let me know if I can assist you further.
Dr Vaishalee
Isotretinoin is given for severe case of recalcitrant nodulocystic acne
Detailed Answer:
Hello and welcome to Ask A Doctor service.
I have reviewed your query and here is my advice.
I will suggest to try all other options including systemic antibiotics before trying isotretinoin especially in young age.
Skin and mucous membrane related side effects occur in almost all patients taking this medicine. Hypersensitivity reactions, pancreatitis, hepatotoxicity, hearing impairment, inflammatory bowel disease may happen. It may also affect the bones, spine and the lipid profile.
After absorption, it produces 3 metabolites. There are some studies to suggest that it gets metabolised by CYP450. One of the metabolites is suggested to be more active than the parent compound. So, if you are poor metaboliser then the side effects will be more.
Hope this answers your query. Let me know if I can assist you further.
Dr Vaishalee
Note: Hope the answers resolves your concerns, however for further guidance of skin related queries consult our Dermatologist.Click here to book a consultation
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
Answered by
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