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If Taking Pantoprazole Daily, Can It Cause A False Positive

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Posted on Fri, 21 Feb 2020
Question: If taking Pantoprazole daily, can it cause a false positive for thc on a urinalysis
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Answered by Dr. AJEET SINGH (1 hour later)
Brief Answer:
False positive for thc on a urinalysis due to Pantoprazole

Detailed Answer:
Hi...
Welcome to "Ask a Doctor" service.
I am Dr Ajeet XXXXXXX

I have gone through your query and here is my opinion.

There has not been a concrete medical evidence but yes there have been multiple reports which have linked a false positive urine screening test for tetrahydrocannabinol (THC) in patients receiving Pantoprazole and other proton pump inhibitors.
The exact mechanism of this result is still unknown.
There is a high level of suspicion because Pantoprazole takes 4-5 days to get eliminated from the body and a repeat test in such patients was negative thereafter.
So it has been shown that some cannabinoids immunoassays are susceptible to cross-reaction errors due to presence PPI metabolites in urine.

Hope that I have answered your query.

Stay healthy and stay blessed.
Regards.
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by : Dr. Nagamani Ng
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Answered by
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Dr. AJEET SINGH

General & Family Physician

Practicing since :1994

Answered : 2151 Questions

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If Taking Pantoprazole Daily, Can It Cause A False Positive

Brief Answer: False positive for thc on a urinalysis due to Pantoprazole Detailed Answer: Hi... Welcome to "Ask a Doctor" service. I am Dr Ajeet XXXXXXX I have gone through your query and here is my opinion. There has not been a concrete medical evidence but yes there have been multiple reports which have linked a false positive urine screening test for tetrahydrocannabinol (THC) in patients receiving Pantoprazole and other proton pump inhibitors. The exact mechanism of this result is still unknown. There is a high level of suspicion because Pantoprazole takes 4-5 days to get eliminated from the body and a repeat test in such patients was negative thereafter. So it has been shown that some cannabinoids immunoassays are susceptible to cross-reaction errors due to presence PPI metabolites in urine. Hope that I have answered your query. Stay healthy and stay blessed. Regards.